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the current decreases. For example, in the presence of 10" 4 M ouabain, it decreases to 5 per cent of its original value. The rate of the active transport of sodium ion across frog skin depends both on the electrochemical potential difference between the two sides of this complex membrane (or, more exactly, membrane system) and also on the affinity of the chemical reaction occurring in the membrane. This combination of material flux, a vector, and 'chemical flux' (see Eq. 2.3.26), which is scalar in nature, is possible according to the Curie principle only when the medium in which the chemical reaction occurs is not homogeneous but anisotropic (i.e. has an oriented structure in the direction perpendicular to the surface of the membrane or, as is sometimes stated, has a vectorial character). It is assumed that the chloride ion is transported passively across the membrane. Using an approach similar to the formulation of Eqs (2.1.2), (2.3.26) and (2.5.23), relationships can be written for the material fluxes of sodium and chloride ions, 7Na+ and Jcr (the driving force is considered to be the electrochemical potential difference), and for the flux of the chemical reaction, / ch : Jcr = / ch = LrlAjUNa+ L22AfiCr + LrrA (6.4.6)



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7.2 T R A nSP O RT C On T RO L PRO TO C O L (TC P)

451 where A/2Na+ and A/2 cr designate the electrochemical potential difference between the inner and outer sides of the skin and A is the affinity of the chemical reaction. As the material flux in the direction from inside to outside is considered as positive, then the coefficients Lu and L22 will also be positive. On the other hand, the coefficients LXr and LrX will be negative. When the electrolyte concentration is identical on both sides of the membrane and A0 M = 0, then AjUNa+ = AJUC, = 0 and Eqs (6.4.6) yield the equation for the current density, 7 = F / N a + = ^ / c h = L1H4





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SYN Synchronizes sequence numbers, only used during connection establishment FIN end of data Closes down one side of the connection Window The window indicates the number of octets that the sender of the ACK is willing to accept before an acknowledgment is sent This is the window size parameter discussed previously, which is used for flow control and effectively represents the amount of buffer the receiver has available Checksum The checksum is used to verify the integrity of the TCP segment The checksum calculation is performed on the TCP pseudo-header and data The pseudo-header is the IP source and destination addresses, TCP header, and the TCP data Urgent Pointer The urgent pointer indicates the location of the urgent data When the URg bit is set, this data is given priority over other data in the data stream.

(6.4.7)

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It should be noted that this and the URg flag are rarely used in modern applications Options Several options are defined for TCP The most common is the TCP Maximum Segment Size (MSS) (details below) The MSS defines the largest segment that will be sent on the TCP connection The value is an estimate by the TCP of the size of datagrams that can be accommodated on the connection without fragmentation Usually each side sends the MTU value of its Layer 2 connection in the MSS field The lower of the two values is then used by both sides as the MSS For example, the MTU of ethernet is 1,514, while the MTU of a PPP connection might be 500 If both ends sent their respective MTUs, then 500 would be chosen as the MSS since the lowest MSS is always chosen.

The resulting current is thus positive and proportional to the rate of the metabolic reaction Several types of active transport (also called a pump) can be distinguished Uniport is a type of transport in which only one substance is transported across the membrane An example is the transport of protons across the purple membrane of the halophilic bacterium Halobacterium halobium, where the energy for transport is provided by light activating the transport protein bacteriorhodopsin The calcium pump in the membrane of the rod-shaped cells of the retina is also light-activated; the active substance is the related rhodopsin On radiation, its prosthetic group, retinal, is transformed from the cis form to the trans form and the protein component is protonated by protons from the cytoplasm After several milliseconds, retinal is converted back to the cis form and the protons are released into the surrounding medium.

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