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2H* Fig. 6.27 An example of Mitchell's 'loops'. The substrate SH2 is oxidized by NAD+ (nicotinamideadeninedinucleotide) and the reduced form transports two protons and two electrons, of which two protons remain in the intracristal space and two electrons are transported back by the Fe-S protein to reduce FMN (flavinmononucleotide), the reduced form of which transports two protons and two electrons in the opposite direction



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With the rapid expansion of the Internet, IPv4 addresses were quickly becoming exhausted by the 1990s, and the sizes of routing tables were expanding exponentially. The response to these problems was the development and adaptation of Classless Inter Domain routing (CIDr). CIDr eliminated the concept of address classes and replaced it with the concept of network prefixes. rather than the first 3 bits defining the network mask, the network prefix alone now defines the network mask. This prefix mask is a method of defining the leftmost contiguous bits in the network portion of the routing table entry. By eliminating the concept of address classes, CIDr allowed for a more efficient allocation of the IP address space. In addition, CIDr supports the concept of route aggregation, thus allowing a single route entry to represent multiple networks. As discussed previously, address planning is extremely important when subnets are first deployed. The subnets should be deployed so that they support the concept of aggregation, and when aggregation or summarization is applied, all subnets can be represented by as few entries as possible in the routing table. If you plan your network addressing from the central core outward to the edges of the network, your addressing scheme should naturally support this sort of hierarchy.





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This can be used in several ways. H+-ATPase plays a key role in oxidative phosphorylation (ATP synthesis) as it transfers protons back into the matrix space with simultaneous synthesis of ATP (with temporary enzyme phosphorylation, cf. page 451). In the presence of certain substances, oxidative phosphorylation is uncoupled, i.e. while the carbonaceous substrate is oxidized, ATP is not synthesized, but can even be hydrolysed to ADP and a phosphate ion. The uncouplers of oxidative phosphorylation belong to the two groups of ionophores, one of which transfers protons across the mitochondrial membrane and the other alkali metal ions. The first group includes the semihydrophobic anions of weak acids such as 2,4-dinitrophenolate, dicumurate, azide, etc. By resonance effects resulting in spreading of the negative charge over the whole structure of these anions, they can pass through the lipid part of the inner membrane of the mitochondrion in the direction of increasing electric potential into the intracristal space, with higher concentration of hydrogen ions. They are then converted into the undissociated form of the corresponding acid, which is transported in the opposite direction into the matrix space, where protons obtained in

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In Figure 5.24, router A supports 256 different subnets with a /24 prefix. rather than advertising all 256 subnets to router B, the administrator can implement route aggregation and advertise them all as 10.10.0.0/16.

468 the intracristal space are dissociated The transport of the anions and of the undissociated acid is passive and decreases both the membrane potential and the activity of hydrogen ions in the intracristal space, so that the energy obtained in the oxidation of the carbonaceous substrate is dissipated as heat The decrease in the hydrogen ion activity in the intracristal space leads to the opposite function of H+-ATPase resulting in ATP hydrolysis The second group of uncouplers includes macrocyclic complexing agents of the valinomycin type (see page 445), which have the strongest effect in the presence of potassium ions The hydrophobic (lipophilic) ionophore freely diffuses through the lipid part of the mitochondrial membrane It binds potassium ions on the intracristal side, which are then passively transported into the matrix space in the complex, simulating proton transport.

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