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By multiplying labor routings by the production quantities listed on the production schedule, the computer system could now report on the number of laborers required for a production facility for each day of production and even itemize the skill classifications needed This was of great assistance in planning out headcount requirements on the production floor Of even greater importance was the use of the same information to determine the capacity usage of each machine in the facility If the MRP II system revealed that the scheduled production would result in a machine overload in any part of the plant, then the production schedulers could reshuffle the schedule to shift work to other machines, thereby avoiding bottlenecks that would keep the company from meeting its production targets The main features of the MRP II system are noted in Exhibit 2-4..



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It was almost as though she had never changed jobs: At the FDA she continued her research on interferon, a highly touted protein that, because of its ability to inhibit viral growth, has been used in treatments for Hepatitis C and several forms of cancer As Zoon sees it, her story shows the value of letting Biologics staff do hands-on research at the FDA Her work sequencing interferon, she said, was instrumental in developing guidance to manufacturers It also shows the depth of CBER staffers feelings about their research The discussion of CBER s scientific tradition was one of several points in our interview when Zoon had to stop, when her face got red, her eyes teared up, and she looked at me with a twisted smile, but she did not quite cry.





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E(Xj,N (t)|Xj (t) = 0). Notice that j (t), j (t) and mj,N (t) are bounded, j (t) is bounded below by a positive constant, and j (t) (t). Substituting in (8.76), we have the bound P {Xj,N Ct,j } {M > x} X(t) = x, Xj (t) = 0 (2 j (t))(j d)/2 2 exp +P

To a certain degree, we ve tried to preserve that culture, but financially it s hard to do The ability to really regulate new products of technology and vaccines requires an understanding of the science I don t think that s valued as much by the FDA today In science there are two main types of research Basic or pure research delves into questions of the fundamental mechanism of whatever is being.

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(where R is the electrical resistance across the sensor element, R0 is a reference resistance, T is the sensed temperature, T0 a reference temperature and b,a1 . . . an are constants). Similar expressions are possible for capacitance type humidity sensors frequently used in building services applications, and for ow measurements many measurements systems make use of the pressure drop across a device such as an ori ce or venturi. This then requires a square root function to translate velocity. Commercial sensors are generally supplied for application with all the appropriate signal conditioning needed to give a more or less linear relationship between the applied input and corresponding output signals, so from a modelling point of view it will frequently be acceptable to assume that the predicted state variables from the model require no further adjustment other than for time response considerations. As to time response, many applications involve measuring variables in rapidly owing streams such as in ducts or pipes, and this will usually result in a very responsive measurement. One commonly encountered situation in which sensor time response does become an issue, however, is when measurements are taken in slow moving or nominally still air, such as is the case with room air temperature measurements. This situation can be described using a rst order model with delay time: f o (s) exp(-tdelay s) = (ts + 1) f i (s) (5.85)

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we may wish to describe a system is the composition two distinct switches. that of H , However, if we describe this system as (SWITCH1 I S ~ I T C ) the composition is indistinguishable from a single switch since two switch processes synchronize the on their shared actions on and off .We must ensure that the actions of each S~ITCH process are not shared, i.e. they must have disjoint labels. To do this we use the process labeling construct.

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