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Before jumping into the details of Project Builder, let s begin by looking at how simple it is to create an application. As you will see, Project Builder enables you to get a basic application shell running in no time. The example application you will build is a Cocoa program that displays an image in a window. You will learn all about Cocoa in chapters 5 and 6, but for now think of it as a collection of object-oriented libraries, or frameworks, for constructing GUI- and non GUI-based applications for Mac OS X. Throughout the book, you will develop many applications. For consistency, you ll store all the projects under a directory called projects, located in your home directory. At this point, create a new folder in your home directory and name it projects. Now, follow these steps:

Kontoyiannis DP et al Zygomycosis in a tertiary-care cancer center in the era of Aspergillus-active antifungal therapy A case-control observational study of 27 recent cases J Infect Dis 2005 Apr 15;191(8):1350 60 [PMID: 15776383] Spellberg B et al Novel perspectives on mucormycosis: pathophysiology, presentation, and management Clin Micro Rev 2005 Jul;18(3):556 69 [PMID: 16020690]

PARACOCCIDIOIDOMYCOSIS (SOUTH AMERICAN BLASTOMYCOSIS)

Technically, when you pass a reference type, the reference itself is passed by value; but the copy that is made is a copy of a reference, and thus that copy points to the same (unnamed) object on the heap as did the original reference object. That is how you achieve the semantics of pass by reference in C# using pass by value. However, that s all behind-the-scenes stuff, and it s acceptable to say that you re passing objects by reference.

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Paracoccidioides brasiliensis infections have been found only in patients who have resided in South or Central America or Mexico Long asymptomatic periods enable patients to travel far from the endemic areas before developing clinical problems Ulceration of the nasopharynx and oropharynx is usually the first symptom Papules ulcerate and enlarge both peripherally and deeper into the subcutaneous tissue Differential diagnosis includes muco-

cutaneous leishmaniasis and syphilis Extensive coalescent ulcerations may eventually result in destruction of the epiglottis, vocal cords, and uvula Extension to the lips and face may occur Eating and drinking are extremely painful Skin lesions may occur, usually on the face Variable in appearance, they may have a necrotic central crater with a hard hyperkeratotic border Lymph node enlargement may follow mucocutaneous lesions, eventually ulcerating and forming draining sinuses; in some patients, it is the presenting symptom Hepatosplenomegaly may be present as well Cough, sometimes with sputum, indicates pulmonary involvement, but the symptoms and signs are often mild, even though radiographic findings indicate severe parenchymatous changes in the lungs The extensive ulceration of the upper gastrointestinal tract may prevent caloric intake and result in cachexia Laboratory findings are nonspecific Serology by immunodiffusion is positive in 98% of cases Complement fixation titers correlate with progressive disease and fall with effective therapy The fungus is found in clinical specimens as a spherical cell that may have many buds arising from it If direct examination does not reveal the organism, biopsy with Gomori staining may be helpful Itraconazole, 100 200 mg orally daily, is the treatment of choice and generally results in a clinical response within 1 month and effective control after 2 6 months

Menezes VM et al Drugs for treating paracoccidioidomycosis Cochrane Database Syst Rev 2006 Apr 19;(2):CD004967 [PMID: 16625617]

This requires two small modifications to the code in Example 8-3. First, change the parameters of the DoubleInt( ) method to indicate that the parameters are ref (reference) parameters:

except for simple aspiration of secondary nodules Joint involvement may require arthrodesis The prognosis is good for lymphocutaneous sporotrichosis; pulmonary, joint, and disseminated disease respond less favorably

da Rosa AC et al Epidemiology of sporotrichosis: a study of 304 cases in Brazil J Am Acad Dermatol 2005 Mar;52(3 Pt 1): 451 9 [PMID: 15761423]

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