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17 C Gather information about the problem, try to reproduce the error, check the device s configuration, and swap the device with a known good one Whenever you troubleshoot a hardware problem, first gather as much information as you can: What is the problem, were there any error messages, has anything changed within the computer This should be the first step because the answers to these questions could tell you enough to pinpoint the problem s source If they do not, try to reproduce the error The device might work this time This step might also give you a chance to note error messages or unusual system activity Next, check the configuration of the device to ensure that it has the proper system resources and a valid device driver If these steps don t resolve the problem, suspect the device itself, and try another in its place A, B, and D are all incorrect because they list the troubleshooting steps in the wrong order Although the steps can physically be performed in any order, it is not efficient to do so For example, if an error points to a missing floppy disk, you will have wasted a lot of time by replacing the drive first 18 A You can rule out the hard drive s configuration as the cause of this problem If the computer was configured incorrectly, the application would not work at all and the computer might not even boot properly Therefore, you must turn your attention to the application as the cause of the problem B, an improper installation of the application, is incorrect because this might be the cause of the problem If the application was installed with missing, misplaced, or corrupt files, certain functions of the application (including its ability to save files) might be disrupted If this is the case, uninstall, then reinstall the application C, an improperly written application, is also incorrect If the application contains flaws (bugs), it might not perform certain actions properly If this is the case, it means that the problem is in the application s code Check for manufacturer updates or patches to resolve the problem D, insufficient system requirements, is also incorrect because this might be causing the problem If the system s processor or memory capacity is insufficient to run the application, the computer might respond by being unable to fulfill a particular request, causing the computer to lock up 19 C You should restart the computer In some cases, applications can use computer resources, such as memory or processor time, and not release them, even when the application is closed By restarting the computer, you will remove the application from memory and/or cause it to release any system resources A, obtain a manufacturer s patch for the game, and D, reinstall the game, are incorrect because these procedures are typically used when an application contains corrupt or improper instructions Since the game worked originally, this is not likely the case Furthermore, it is typically more time consuming to install a patch or reinstall an application than it is to reboot the system B, troubleshoot the printer, is incorrect The printer is also an unlikely suspect in.

been implicated as the cause of the pain of migraine headache, but the reason for its release and the relationship to changes in blood ow is unclear Blau and Dexter and also Drummond and Lance are con dent that the presence or absence of headache does not depend on extracranial vascular factors These authors point to their ndings that occlusion of blood ow through the scalp or common carotid circulation fails to alleviate the pain of migraine in onethird to one-half the patients Alternatively, Lance has suggested that the trigeminal pathways are in a state of persistent hyperexcitability in the migraine patient and that they discharge periodically, perhaps in response to a hypothalamic stimulus This is in keeping with current theories regarding the trigeminovascular complex discussed above as well as with evolving ideas on central sensitization to pain due to repeated noxious stimulation from one region Also, there is a body of circumstantial evidence that serotonin acts as a humoral mediator in the neural and vascular components of the migraine headache This evidence and the role of other factors in the pathogenesis of migraine have been reviewed in detail by Lance and Goadsby The potential role of nitric oxide has been mentioned, and its importance in migraine is bolstered by the observation that drugs blocking its production ameliorate the headache The foregoing observations leave a number of questions unanswered Is one to conclude that migraine with and without aura are different diseases, involving extracranial arteries in one instance and intracranial ones in another Is the circulatory change the primary cause of headache, or is it a secondary or coincidental phenomenon Is diminished neuronal activity (spreading depression) the primary cause of neurologic symptoms (it seems so) and headache (unclear), and is the diminished regional blood ow secondary to reduced metabolic demand Why are the posterior portions of the brain (visual auras) so often implicated No nal reconciliation of all these con icting data is possible at this time and the mechanism of migraine remains incompletely explained Several aspects seem clear, however The authors continue to favor the unique mechanism of spreading depression as the best explanation of the neurologic de cit, as well as the view that a trigeminal vascular re ex, which releases vasogenic substances into the vessel walls, is the most plausible explanation of the headache The neural mechanisms that underlie these changes and precisely what is altered by the genetic predisposition to migraine are unresolved There are fairly consistent vascular changes during the aura (reduced regional ow, mainly in posterior regions of the cerebrum) and, at the same time, dilation of both basal brain and scalp vessels; but the connection of this change in caliber to pain, the traditional explanation for headache, is not certain Perhaps emotion, fatigue, fasting, mild head injury, and so forth serve, in vulnerable individuals, to activate the neural mechanisms Diagnosis Neurologic migraine should occasion no dif culty in diagnosis if a good history is obtained The dif culties come from a lack of awareness that (1) a progressively unfolding neurologic syndrome may be migrainous in origin, (2) the neurologic disorder may occur without headache, and (3) recurrent migraine headaches take many forms, some of which may prove dif cult to distinguish from the other common types of headache Some of these problems merit elaboration because of their practical importance The neurologic part of the migraine syndrome may resemble a transient ischemic attack, focal epilepsy, the clinical effects of a slowly evolving hemorrhage from an arteriovenous malformation.

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