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From the chain rule, qID qID qVD qV qVD qV Then we can express the current as, ! qID qI 1 R1 qID 1 qV qVD ! qV qID 1 rD rb k R1 qVD 1 Solving for the current as a function of the voltage [7,8], qM aIE Igen qI qV qV aM R1 1 1 1 ! rb 1 1 aM rb R 1 1 ! qID 1 1 rD rb k R1 1 qVD qID qVD From this form, the electrical stability of the circuit can be determined. When the partial derivative of current with respect to voltage is positive, the circuit is electrically stable. When the partial derivative of current with respect to voltage is negative, the system is electrically unstable. The condition of electrical instability is when the denominator is equal to zero, or qM aIE Igen qI qV 1 aM qV 1 R1 1 1 From this expression, when the denominator is equal to zero, the system transitions from a stable network to an unstable network. Hence, 1 aM R1 0 1 1



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If the relationship is heterosexual, do both partners understand (at least) that pregnancy can result from sexual intercourse Where the relationship is heterosexual, do both know what contraception means and how to use methods of contraception Do both partners understand that there is a risk of sexually transmitted diseases, particularly when the sexual activity includes oral or anal penetration, and know how to engage in safer sex If pregnancy is a possibility, have both people been given adequate access to genetic counselling and have they been informed and understood issues relating to parenting (including the reality that fostering may be required) Have both people been offered sex education





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(Wheatley, 1997), yielding a slightly better side effect pro le Meta-analyses evaluating theses studies have found SJW to be between 15 to 3 times more likely to produce an antidepressant response as compared to placebo, and to be equivalent in ef cacy to tricyclic antidepressants, (see H L Kim, Streltzer, & Goebert, 1999; Linde et al, 1996) Research on the biological mechanisms through which SJW may exert its antidepressant effects suggests that similar to popular pharmaceutical antidepressants, SJW in uences amine levels The main dif culty in studying the biological mechanism of SJW pertains to the fact that several active constituents have been identi ed from H perforatum (Nahrstedt & Butterweck, 1997) including hypericin (Muller, Rolli, Schafer, & Hafner, 1997), and hyperforin (Chatterjee, Bhattacharya, Wonnemann, Singer, & Muller, 1998; Laakmann, Schule, Baghai, & Kieser, 1998; Muller et al, 1997, 1998; Schellenberg, Sauer, & Dimpfel, 1998).

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Overall, research indicates that SJW may inhibit the synaptosomal reuptake of serotonin, dopamine, and norepinephrine (Muller et al, 1997, 1998; Muller & Rossol, 1994; Neary & Bu, 1999); upregulate postsynaptic serotonin receptors (TeufelMayer & Gleitz, 1997); and interfere with the central dopaminergic system (Butterweck, Wall, Lie ander-Wulf, Winterhoff, & Nahrstedt, 1997; Franklin et al, 1999) Studies demonstrate that the main advantage to SJW is its more preferable side effect pro le and tolerability to synthetic antidepressants The most common adverse side effects included gastrointestinal symptoms (06%), allergic reactions (05%), tiredness (04%), and restlessness (03%) (Woelk, Burkard, & Grunwald, 1994) In addition, hypericum has been found to be safer with regard to cardiac function than tricyclic antidepressants (Czekalla, Gastpar, Hubner, & Jager, 1997).

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