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Women taking tamoxifen who still have a uterus are at a higher risk of developing endometrial hyperplasia and endometrial carcinoma (risk ratio of 2.53) compared to patients who took placebo in a randomized trial.8 Other casecontrolled studies have also shown an increased risk of developing endometrial hyperplasia while on tamoxifen, especially for postmenopausal women.29 Despite this, the absolute risk of endometrial cancer in a woman on tamoxifen is less than 1 in 1000.11 Therefore, women on tamoxifen should be counseled about their increased risk of both endometrial hyperplasia and carcinoma, and any woman taking tamoxifen should be instructed to report any abnormal vaginal bleeding, especially if she is postmenopausal.16 Premenopausal women appear to have no difference in the rates of endometrial hyperplasia or carcinoma while on tamoxifen and therefore



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19 Field RJ, Noyes RM Oscillations in chemical systems IV Limit cycle behavior in a model of a real chemical reaction J Chem Phys 1974;60:1877 1884 20 Fredkin F, Toffoli T Conservative logic Int J Theor Phys 1982;21:219 253 21 Gerhardt M, Schuster H, Tyson JJ A cellular excitable media Physica D 1990;46:392 415 22 Grill S, Zykov VS, M ller SC Spiral wave dynamics under pulsatory modulation of exu citability J Phys Chem 1996;100:19082 19088 23 Hartman H, Tamayo P Reversible cellular automata and chemical turbulence Physica D 1990;45:293 306 24 KItahata H, Aihara R, Magome N, Yoshikawa K Convective and periodic motion driven by a chemical wave J Chem Phys 2002;116:5666 25 Kitahata H, Yoshikawa K Chemo-mechanical energy transduction through interfacial instability Physica D 2005;205:283 291 26 Klein R Concrete and abstract Voronoi diagrams Berlin: Springer-Verlag; 1990 27 Kuhnert L.





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8. Click the triangle next to the Sphere layer in the Animation (Timeline) palette to show the layer properties. 9. Click the Time-Vary Stop Watch button next to the Position property.

A new photochemical memory device in a light sensitive active medium Nature 1986;319:393 28 Kuhnert L, Agladze KL, Krinsky VI Image processing using light-sensitive chemical waves Nature 1989;337:244 247 29 Kusumi T, Yamaguchi T, Aliev R, Amemiya T, Ohmori T, Hashimoto H, Yoshikawa K Numerical study on time delay for chemical wave transmission via an inactive gap Chem Phys Lett 1997;271:355 360 30 Margolus N Physics-like models of computation Physica D 1984;10:81 95 31 Markus M, Hess B Isotropic cellular automata for modelling excitable media Nature 1990;347:56 58 32 Mills J The new computer science and its unifying principle: complementarity and unconventional computing Position Papers International Workshop on the Grand Challenge in Nonclassical Computation; New York; 2005 Apr 18 19 33 Motoike IN, Yoshikawa K, Iguchi Y, Nakata S Real-time memory on an excitable eld Phys Rev E 2001;63:036220 34 Motoike IN, Yoshikawa K.

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is the remaining 90 percent that interests me The 5 percent who do not need controls must accept them as the cost of doing business The 5 percent that may try to evade them must be identified and dealt with in an appropriate manner For the remaining 90 percent, controls are certainly constraints on their behavior but also, I would hope, instructive in explaining the organization s view of how one is expected to comport one s self They are designed and in place as a ready reference guide, to be consulted when uncertainty or temptation appears Perhaps Leuci has done us a great service in suggesting we resist the temptation to focus on the anomalies the good and the evil and pay most attention to the middle When thinking about the law enforcement concepts we have discussed, especially in New York City, one is tempted to think about numbers.

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