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Compress PDF , PPT, Word, Excel, PNG, TIFF & JPEG files free online . No file limits, no registration & no watermarks; just smaller, easy to share, high-quality files ... Initially introduced as Botox , this product was first used for cosmetic purposes in 1981 Botox Cosmetic, still usually referred to as Botox, was approved by the FDA in 2002 for treatment of (glabellar) frown lines Botox is formed from fermented cultures of C botulinum The cultures are subjected to autolysis, releasing a 900 kD toxic complex Prior to placement in storage vials, the compound is diluted with human serum albumin The manufacturers then freeze dry and seal the toxin One vial of Botox contains 100 U of BTX-A DILUTION AND STORAGE Physicians do not agree on the optimal dilution ratio for the toxin or on how long the toxin retains its potency after dilution However, Klein published a survey of expert Botox users and found that most of them use a dilution of 25 cc per 100U vial11 This dilution was used in the Allergan FDA trials as well Reports in the literature support the use of 1 cc to 10 cc dilutions11 See Table 22-2 for dilution guidelines The 100-U bottle of Botox is diluted with 09% saline Preservative-free saline was recommended initially until studies showed that pain perception was decreased when preservativecontaining saline was used12 When diluting the bottle, care must be taken to gently inject the saline into the bottle to prevent foaming and bubbles, which may denature the toxin and decrease its potency Many physicians remove the TABLE 22-2 The Amount of Saline Used to Dilute Botox Determines the Number of Units in Each 01 cc DILUTION TABLE FOR BOTOX VOLUME OF DILUENT ADDED (CC) 10 20 25 30 NUMBER OF UNITS PER 01 CC 10 5 4 33 pdf compressor software free download for windows 10 64 bit: Download pdf compressor 32 bit pc for free (Windows) pdf size reducer software online 8 Best PDF Compressor for Mac and Windows | Mashtips
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Using this free online PDF compressor , you can make sure that both uploading or sending large PDF files is possible. Reduce the file size of your PDF . rubber stopper before adding the saline, which prevents the rapid addition of saline to the bottle because of the vacuum of the bottle and helps avoid leaving a few expensive drops of BTX-A in the vial Novice practitioners should be advised to never insert the needle of the syringe that is to be used for injection into the rubber stopper This would make it dull and increase the pain on injection In addition, it is important not to shake the bottle or flick the syringe to eliminate air bubbles as agitation of the toxin may lead to loss of potency Once the BTX-A has been diluted with saline, it begins to lose potency, but the point at which the potency losses become clinically significant is unknown Many authors suggest that BTX-A should be used within 48 hours; however, a few authors state that Botox may remain in the refrigerator up to 4 weeks13 If one plans to keep Botox for an extended period of time, preservative-containing saline should be used and the reconstituted Botox should be kept in a refrigerator In the primary author s experience, the best Botox is fresh Botox and should be used within 24 hours of dilution Botox should not be refrozen once prepared as this also causes a definite loss of potency, due to the formation of ice crystals pdf compressor software free download for windows 8 64 bit Best PDF Compression Software to Reduce PDF File Size - LightPDF
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