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Trivia time: As you can see, the ASCII representation of the header bytes (0x5A4D) is MZ. These are the initials of Mark Zbikowski, one of the original architects of MS-DOS.



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For many decades androgens have dominated hair growth research A commonly prescribed drug for hair loss, finasteride (Propecia ), blocks the conversion of testosterone to DHT by inhibiting the enzyme 5- -reductase type II Regarding treatment of hair loss, finasteride is a pregnancy category X, thus contraindicated for women in their childbearing years who intend to have children It is indicated for men with male pattern hair loss, and may be effective for the treatment of androgenetic alopecia, or male pattern hair loss, in postmenopausal women16 As both androgen and estrogen receptors are found in the hair follicles, theoretically either of them can be targeted for the treatment of patterned hair loss Furthermore, as the aromatase enzyme is located in the hair follicle and the sebaceous gland, these tissues can be both target and source for estrogen or testosterone While ER- is found in the bulge region, ER- and androgen receptors are found in the dermal papilla The hair cycle is self-renewing because of the presence of stem cells in the bulge It is thought that cells in the dermal papilla send a signal to the stem cells in the bulge to differentiate and ultimately restart the anagen phase While it is known that the dermal papillae regulate hair growth and have receptors for androgens and ER- , the sequence of signals that regulate hair growth has not been elucidated What is clear is that estrogens and androgens are intimately involved in this process Gender differences in hair exist as evidenced in the commonality of androgenetic alopecia, which occurs but is much less common in women This gender difference may be attributable more to the inherent enzyme content within hair follicles than to serum hormone levels For instance, Sawaya and Price17 examined the levels of 5- -reductase types I and II, aromatase, and androgen receptors in hair follicles of women and men with androgenetic alopecia and found that the women had a six-fold greater aromatase level in frontal hair follicles than the men, giving them the ability to convert weaker sex hormone precursors into stronger ones These authors also determined that the women had threeand three-and-a-half-fold less 5- -reductase types I and II, respectively, in their hair follicles than the men did in their frontal hair follicles, thus reducing the women s ability to synthesize the more potent form of male hormone, DHT, which is responsible for hair miniaturization and eventual loss17 Sawaya and.





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function Get-MagicNumber ($path) Set $OFS to { empty string $OFS="" $mn = Get-Content -encoding byte $path -read 4 -total 4 $hex1 = ("{0:x}" -f ($mn[0]*256+$mn[1])).PadLeft(4, "0") $hex2 = ("{0:x}" -f ($mn[2]*256+$mn[3])).PadLeft(4, "0") [string] $chars = $mn| %{ if ([char]::IsLetterOrDigit($_)) { [char] $_ } else { "." }} "{0} {1} '{2}'" -f $hex1, $hex2, $chars Emit } output

1 2 = sin( /2) = 1 = 2

There s not much that s new in this function. Again, we set the output field separator string to be empty B. We extract the first four bytes as two pairs of numbers formatted in hex C and also as characters D if they correspond to printable characters. Finally, we format the output E as desired. From these examples, we see that Get-Content allows us to explore any type of file on a system, not just text files. For now, though, let s return to text files and look at another parameter on Get-Content: -Delimiter. When reading a text file, the default line delimiter is the newline character.

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Actually, the end-of-line sequence on Windows is generally a two-character sequence: carriage return followed by newline. The .NET I/O routines hide this detail and let us just pretend it s a newline. In fact, the runtime will treat newline by itself, carriage return by itself, and the carriage return/newline sequence all as end-of-line sequences.

Note that while we calculated Eq (117) for real z such that 0 < z < 1, the result can be extended using analytic continuation EXAMPLE 115 Using the gamma function, show that

This parameter lets you change that. With this new knowledge, let s return to the word-counting problem we had earlier. If we set the delimiter to be the space character instead of a newline, we can split the file as we read it. Let s use this in an example.

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