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osteoclastogenic activity by activating RANKL via TLR-2 and TLR-4 activation Immunol Lett 2007;110:54 Renshaw M, Rockwell J, Engleman C, et al Cutting edge: impaired Toll-like receptor expression and function in aging J Immunol 2002;169:4697 van DD, Mohanty S, Thomas V, et al Age-associated defect in human TLR-1/2 function J Immunol 2007;178:970 Kim J, Ochoa MT, Krutzik SR, et al Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses J Immunol 2002;169:1535 Nagy I, Pivarcsi A, Koreck A, et al Distinct strains of Propionibacterium acnes induce selective human beta-defensin-2 and interleukin-8 expression in human keratinocytes through toll-like receptors J Invest Dermatol 2005;124:931 Curry JL, Qin JZ, Bonish B, et al Innate immune-related receptors in normal and psoriatic skin Arch Pathol Lab Med 2003;127:178 Krutzik SR, Ochoa MT, Sieling PA, et al Activation and regulation of Toll-like receptors 2 and 1 in human leprosy Nat Med 2003;9:525 Birkedal-Hansen H: Matrix metalloproteinases Adv Dent Res 1995;9:16 Dayer JM, Beutler B, Cerami A Cachectin/ tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts J Exp Med 1985;162:2163 Postlethwaite AE, Raghow R, Stricklin GP, et al Modulation of fibroblast functions by interleukin 1: increased steadystate accumulation of type I procollagen messenger RNAs and stimulation of other functions but not chemotaxis by human recombinant interleukin 1 alpha and beta J Cell Biol 1988;106:311 Wlaschek M, Heinen G, Poswig A, et al UVA-induced autocrine stimulation of fibroblast-derived collagenase/MMP-1 by interrelated loops of interleukin-1 and interleukin-6 Photochem Photobiol 1994; 59:550 Zhang Y, McCluskey K, Fujii K, et al Differential regulation of monocyte matrix metalloproteinase and TIMP-1 production by TNF-alpha, granulocyte-macrophage CSF, and IL-1 beta through prostaglandindependent and -independent mechanisms J Immunol 1998;161:3071 Stricklin GP, Welgus HG Human skin fibroblast collagenase inhibitor Purification and biochemical characterization J Biol Chem 1983;258:12252 Edwards DR, Murphy G, Reynolds JJ, et al Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor EMBO J 1987;6:1899.

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By doing a dir of the path function:/mkdir, you can see the mkdir exists and is a function. And of course wild cards can be used, so we could have just written mk* as shown.

Since we obtained two different values for the limit by approaching the origin in two different directions, the limit cannot exist

PS (8) > dir function:/mk* CommandType ----------Function Name ---mkdir Definition ---------param([string[]]$pat...

And, if you just do dir on the function drive, you ll get a complete listing of all functions. Let s do this but just get a count of the number of functions.

1 =0 f (z)

PS (10) > function clippy { "I see you're writing a function." }

PS (12) > dir function:clippy CommandType ----------Function Name ---clippy Definition ---------"I see you're writin...

(216)

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Running dir on function:clippy gives us the function definition entry for this function. Now let s remove it.

PS (14) > (dir function:/).count 78 PS (15) > dir function:clippy Get-ChildItem : Cannot find path 'clippy' because it does not ex ist. At line:1 char:4 + dir <<<< function:clippie

Long-time Microsoft Office users will no doubt be feeling an intense burst of satisfaction with this last example. We ve all longed to eradicate that annoying paperclip assistant , and at last we have the pleasure, if in name only. And, even more amusing: Microsoft Word doesn t even recognize clippy it keeps trying to autocorrect to clippie . Some unresolved issues perhaps

The limit as z goes to in nity is equal to if and only if 1 lim f = z 0 z (217)

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50 Herrlich P, Sachsenmaier C, Radler-Pohl A, et al The mammalian UV response: mechanism of DNA damage induced gene expression Adv Enzyme Regul 1994;34:381 51 Gebbia JA, Coleman JL, Benach JL Selective induction of matrix metalloproteinases by Borrelia burgdorferi via toll-like receptor 2 in monocytes J Infect Dis 2004;189:113 52 Elass E, Aubry L, Masson M, et al Mycobacterial lipomannan induces matrix metalloproteinase-9 expression in human macrophagic cells through a Tolllike receptor 1 (TLR1)/TLR2- and CD14dependent mechanism Infect Immun 2005;73:7064 53 Lee S, Hong J, Choi SY, et al CpG oligodeoxynucleotides induce expression of proinflammatory cytokines and chemokines in astrocytes: the role of c-Jun N-terminal kinase in CpG ODN-mediated NF-kappaB activation J Neuroimmunol 2004;153:50 54 Li VW, Li WW, Talcott KE, et al Imiquimod as an antiangiogenic agent J Drugs Dermatol 2005;4:708 55 Kligman A, Zhen Y, Sadiq I, et al Imiquimod 5% Cream reverses histologic changes and improves appearance of photoaged facial skin Cos Derm 2006; 19:704 56 Liu PT, Krutzik SR, Kim J, et al Cutting edge: all-trans retinoic acid down-regulates TLR2 expression and function J Immunol 2005;174:2467 57 Dedieu S, Lefebvre P Retinoids interfere with the AP1 signalling pathway in human breast cancer cells Cell Signal 2006;18:889 58 Kang S, Cho S, Chung JH, et al Inflammation and extracellular matrix degradation mediated by activated transcription factors nuclear factor-kappaB and activator protein-1 in inflammatory acne lesions in vivo Am J Pathol 2005;166: 1691 59 Trivedi NR, Gilliland KL, Zhao W, et al Gene array expression profiling in acne lesions reveals marked upregulation of genes involved in inflammation and matrix remodeling J Invest Dermatol 2006;126:1071 60 Layton AM Optimal management of acne to prevent scarring and psychological sequelae Am J Clin Dermatol 2001;2:135 61 Janssen de Limpens AM The local treatment of hypertrophic scars and keloids with topical retinoic acid Br J Dermatol 1980;103:319 62 Mizutani H, Yoshida T, Nouchi N, et al Topical tocoretinate improved hypertrophic scar, skin sclerosis in systemic sclerosis and morphea J Dermatol 1999; 26:11.

The techniques we ve covered in this section allow you to manipulate the functions defined in your current session. As with any drive, you can list the functions, create new ones, delete them, and rename them. But regardless, all these functions will disappear when the session ends and you exit PowerShell. What about permanent functions How do you define those This is where scripts come in, and we ll cover that topic next.

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