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FIGURE 4.8 The volcano plot of signi cance versus fold change. This gure is a plot of the signi cance (p-value from ANOVA test, on a log-10 scale) against fold change (log-2 ratio), for testing the hypothesis on the differences in gene expression levels between the AML group and the ALL group in the acute leukemia data set. The horizontal line represents a signi cance level threshold of 0.05. The two vertical lines represent the absolute fold-change threshold of 2. The genes plotted in the two A regions are detected as signi cant by both methods, while the genes plotted in region C are detected as insigni cant by both methods. This type of plot demonstrates two types of errors that occur with the ratio-based method: false positive errors plotted in the two D regions, and false negative errors plotted in the B region. A common practice is to identify only the genes plotted in the two A regions as differentially expressed and discard the genes plotted in the B region.



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Using design levels from CMOS and bipolar devices, new hybrid elements and new ESD diode elements can be formed to produce ESD input node structures. For ESD diode elements, subcollector implants, trench isolation (TI), and deep trench (DT) isolation structures can be used to enhance the performance of the diode structures [27]. Some examples of hybrid dual-well primitive O[1] p-cell diode elements are as follows: STI-de ned p =n-well diode with subcollector implant;





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Product Promotion Cycle Lawrence explains that it is essential to anticipate and plan for the typical product promotion cycle (see Exhibit 12.2). Typically, there s a surge in sales with the initial product introduction and market expansion, followed by what I call the trough of disillusionment, when sales fall, he says. But you have to get past this to reach the slope of enlightenment and, finally, the plateau of productivity, where sales settle into a sustainable climb over time. Other People s Money Remain innovative and entrepreneurial in order to do more with less, says Lawrence. To extend your limited marketing budget, Lawrence recommends what he calls the judicious use of other people s money. This means coming up with nontraditional ways to promote products, such as encouraging your customer retail outlets to promote your product through joint advertising efforts, to help you stretch your marketing dollars. Qualcomm extensively uses contests, product-launch events, and press conferences. Remember, a press interview or event is not an intellectual exercise, he says. It s an opportunity to deliver specific newsworthy messages to specific audiences through the filter of a reporter. He adds, Your goal is to increase the number of impressions you create via public relations. INTERNAL EXPORT COMPLIANCE PROGRAM With fines and penalties for export violations up sharply, along with everescalating government compliance requirements, maintaining a professional and up-to-date internal compliance program (ICP) for exports has never been more important. At an export compliance seminar, veteran compliance expert Anne Hilsabeck, president and founder of AMH Customs Consultants, updated export professionals on the latest best practices for ensuring compliance.

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Solomons, L, & Stein, G (1896) Normal motor automatism Psychological Review, 3, 492 512 Sun, R, Slusarz, P, & Terry, C (2005) The interaction of the explicit and the implicit in skill learning: A dual-process approach Psychological Review, 112, 159 192 Titchener, E B (1908) Lectures on the elementary psychology of feeling and attention New York: Macmillan Todd, P M, & Gigerenzer, G (2000) Precis of simple heuristics that make us smart Behavioral and Brain Sciences, 23, 727 741 Treisman, A (1969) Strategies and models of selective attention Psychological Review, 76, 282 299 Ungerleider, L G, & Mishkin, M (1982) Two cortical visual systems In D J Ingle, M A Goodale, & R J W Mansfield (Eds), Analysis of visual behavior (pp 549 586) Cambridge, MA: MIT Press van der Kamp, J, Savelsbergh, G J P, & Oudejans, R D D (2003).

The development and learning of the visual control of movement: An ecological perspective Infant Behavior and Development, 26, 495 515 Vereijken, B, van Emmerik, R E A, Whiting, H T A, & Newell, K M (1992) Free(z)ing degrees of freedom in skill acquisition Journal of Motor Behavior, 24, 133 142 Vicente, K J, Thornton, D C, & Moray, N (1987) Spectral analyses of sinus arrhythmia: A measure of mental effort Human Factors, 29, 171 182 Wakelin, D R (1967) The role of the response in psychological refractoriness Acta Psychologica, 40, 163 175 Welch, J C (1898) On the measurement of mental activity through muscular activity and the determination of a constant of attention American Journal of Physiology, 1, 253 306 Welford, A T (1967) Single channel operation in the brain Acta Psychologica, 27, 5 22 Wickens, C D (1979).

Figure 15-5 Examples of raw and flat-field-corrected CCD images. (a) Raw image. (b) Corrected image. (c) Flat-field frame. Notice that optical faults from uneven illumination are removed.

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