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Type I IFNs activate the JAK/STAT signal transduction pathway by binding to the IFN-a/b receptor (IFNAR) The cytoplasmic tails of IFNAR are associated with tyrosine kinases (JAK and TYK), which phosphorylate signal transducers and activators of transcription (STAT)5 STATs are latent transcription factors that, upon phosphorylation, dimerize and form complexes with interferon response factors (IRFs) These complexes move to the nucleus and bind to interferon-stimulated regulatory elements (ISRE)6 Several genes are then transcriptionally stimulated Of these gene products, many contribute to the antiviral actions of the host immune response PKR is a double-stranded RNA (dsRNA)-dependent serine/threonine kinase In the presence of dsRNA, most likely produced from the viral genome itself or formed from its replication or convergent transcription, PKR phosphorylates the a subunit of the eukaryotic initiation factor eIF-2. 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At the same time, the cell must use its pathways that regulate cell proliferation to stop viral proliferation. Viruses vary in their ability to circumvent the host interferon response. In general, DNA viruses produce less dsRNA and initially are therefore less potent inducers of IFN.10 However, viral evasion tactics exist at much more sophisticated levels. Bray established the key role of type-1 IFN in the resistance of mice to the Ebola virus infection, showing that signi cant compromise of the interferon response gave rise to disease progress resembling that in primates.11 In line with these latter observations, Harcourt et al.12 found that induction of the major histocompatibility complex class I family of genes, OAS, interleukin-6 (IL-6), PKR, interferon (IFN) regulatory factor-1, and intercellular adhesion molecule-1 (ICAM-1) by dsRNA in human umbilical vein endothelial cells was suppressed by infection with the lovirus Ebola-Zaire. Likewise, Ebola and Marburg viruses each could infect dendritic cell cultures and support exponential viral replication without releasing. Adenovirus (AV), Epstein-Barr virus (EBV), and human immunode ciency virus type 1 (HIV-1) all encode small RNA ranscripts that bind to the active site for dsRNA binding.20,45,53,54 In uenza virus NS1 protein binds directly to PKR but has also. ECC200 Encoder In VS .NET Using Barcode encoder for .Related: PDF417 Generation VB.NET , Excel ISBN Generator , .NET WinForms Code 128 Generating xsd file for "BarcodeDemoData.mdb", which defines all above three columns in Customer table, also define one extra column named "Barcode", with data type "xs ase64Binary". .Related: Excel Barcode Generating Library, Generate Barcode RDLC .NET Winforms , RDLC C# Barcode Generation Below is an example about this step and we will use Code 128 barcode to encode Customer Account number. 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