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adefovir17 may hasten its use by the viral enzyme This group, as well as changes in the rest of the molecule, bring the process to a halt once incorporated, killing the infected cell The early promise of modi ed nucleosides as compounds to treat HIV infection did not halt the search for candidates from other chemical classes Problems inherent in the nucleoside included the relatively high cost of starting materials, some drugrelated side effects, as well as the observation that prolonged use led to the development of drug-resistant strains By the middle 1980s, laboratories in both the National Cancer Institute18 and pharmaceutical companies had in place high-capacity, semiautomated screens for identifying compounds that protected cells in tissue culture from the effects of HIV A number of compounds were uncovered by these tests that bore no structural relation to the nucleoside (Fig 7).



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This method is used when referencing an element or attribute from other namespaces For example, you could combine the elements from several namespaces into another XML document by using explicit namespace declaration, as follows: <weather:temperature xmlns:weather="http://mdcom/xml/weather"> 80 </weather:temperature> <liquid:temperature xmlns:liquid="http://mdcom/xml/liquid"> 150 </liquid:temperature> The name preceding the colon is called the prefix It serves as a shorthand notation so that references to the actual namespace URI don't need to be repeated everywhere an element or attribute is used within the document Instead, you simply use the prefix to refer to the namespace The only requirement for the shorthand name is that it must be unique within the context of the document that you're using Using namespaces in this way eliminates naming conflicts and guarantees that any two elements that have the same name must come from the same vocabulary.





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For example, the weather temperature is clearly distinguished from the liquid temperature You'll find explicit namespace declarations used in many places within the XML documents that are an integral part of the Web Services architecture..

FDD operating mode is intended for use in macrocells and microcells, whereas TDD operating mode is intended for use in picocells. In the TDD mode it is more dif cult to handle large propagation delays between the MS and BS, as transmitting and receiving timeslots might overlap. Therefore, it can only be employed in picocells. However, TDD has the advantage that big asymmetries in throughput on the downlink and uplink can be easily supported. This is particularly important for applications like Web browsing for which the MS receives much more information than it transmits. For medium access, TDD mode employs JD-TCDMA and FDD mode WCDMA. We will not, however, consider the TDD mode further in this chapter.

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In spite of their chemically very different structures, nevirapine,19 delaviridine,20 and efavirenz21 all act by a very similar mechanism Each of these molecules binds directly to a site on the reverse transcriptase enzyme given the name non nucleoside reverse transcriptase inhibitor (NNRTI) binding pocket It has been shown that the binding interaction of the drugs with this site leads to distortions of the three-dimensional shape of the enzyme; this change in con guration impedes enzyme function22 The relatively low toxicity of the compounds comes from the fact that they have no af nity for corresponding enzymes involves in DNA replication of normal cells Although effective in vitro, the NNRTIs elicited the evolution of resistant strains even more quickly than the nucleoside transcriptase inhibitors They are, as a consequence, almost always administered as part of a multidrug cocktail.

Is it allowed under the law Is this garnishment legal under the governing laws Where the employee works and lives can determine what garnishments can be processed For example: Some states do not permit creditor garnishments If this employee works in such a state, but the employer is located in a state that does allow this type of garnishment, then the employee s work state laws would prevail Also, are there other, higher priority garnishments ahead of it These are some of the laws that the payroll department must research to decide if the garnishment is legal and can be processed Step 4 Answer Back Once the garnishment has been determined to be valid, it must be processed through the payroll and the rst step after verifying the garnishment is to answer it.

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