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It has been suggested that women taking oral contraceptives may have an increased requirement for B6 Certain drugs such as isoniazid used in the treatment of tuberculosis may increase the requirement for B6 and supplements are usually given when these drugs are used Supplements of B6 interfere with the actions of L-Dopa used in the treatment of Parkinson s disease, probably by increasing its peripheral conversion to dopamine; pyridoxal phosphate is a co-factor for the decarboxylase enzyme that converts dopa to dopamine FSA (2003) suggest that average UK intakes of B6 from the diet are around 2 mg/day with the highest consumers taking in around double this amount At the extremes some supplements may provide as much as 100 mg/day although most provide up to 10 mg/day In animal studies, it has been shown that B6 has the potential to be neurotoxic.



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Very high doses cause abnormalities of gait and balance and can produce permanent, histologicallyveri ed peripheral nerve damage Largely on the basis of animal studies, FSA (2003) suggested that a lifetime dose of 10 mg/day should have no harmful effects They were unable to judge the risk posed by taking up to 200 mg/day by humans They suggested that whilst this might well be negligible in the short term they did not have suf cient data to offer that assurance There are several reports of people developing sensory neuropathy manifested initially by a tingling sensation in the hands and feet when taking large supplemental doses of B6 (FSA 2003) Vitamin B12 (cobalamins) Vitamin B12 is comprised of several complex, cobalt-containing compounds that are present in animal foods.





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The synthetic compound cyanocobalamin is widely used in vitamin supplements and so less frequently is hydroxocobalamin; these two forms are the only ones on the permitted list of the EU Food Supplements Directive The vitamin is initially synthesised in micro-organisms (bacteria, fungi and algae) and is present in meat (especially offal), sh, eggs and milk Plant tissue contains no B12 per se but anything that is contaminated with micro-organisms, such as mould, will contain B12 and so will the root nodules of some legumes where it is synthesised by the bacteria they contain A strict vegetarian or vegan diet will theoretically contain no B12 but contamination by microorganisms, insect remains or faecal matter will provide some B12 Healthy young omnivorous adults will have several years supply of vitamin B12 stored in their livers The adult RNI for vitamin B12 is extremely small at 1.

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5 g/day; the American RDA is 24 g/day This means that even the amounts present in contaminants of food coupled with some contribution from intestinal bacteria may be suf cient to prevent overt symptoms of de ciency in people whose diet theoretically does not contain any of the vitamin Algal preparations such as Spirulina and Chlorella are often marketed as sources of vitamin B12 that are suitable for strict vegetarians (see 8); the B12 in Spirulina is almost certainly not biologically active in humans Vitamin B12 and folic acid are essential for the synthesis of the nucleotide thymidylate which is an essential component of DNA This means that de ciency of either of these vitamins interferes with normal cell division and this leads to a megaloblastic anaemia in which large unstable red cells enter the circulation this ultimately causes a severe and potentially fatal anaemia.

in the Bay of Biscay which is closed by this rotation. Geologic evidence (Section 3.3) and information provided by magnetic lineations in the Atlantic (Section 4.1.7) indicate that the reconstruction represents the continental con guration during late Triassic/early Jurassic times approximately 200 Ma ago. Examination of Fig. 3.2 reveals a number of overlaps of geologic signi cance, some of which may be related to the process of stretching and thinning during the formation of rifted continental margins (Section 7.7). Iceland is absent because it is of Cenozoic age and its construction during the opening of the Atlantic postdates the reconstruction. The Bahama Platform appears to overlap the African continental margin and mainland. It is probable, however, that the platform represents an accumulation of sediment capped by coral on oceanic crust that formed after the Americas separated (Dietz & Holden, 1970). Similarly, the Niger Delta of Africa appears to form an overlap when in fact it also developed in part on oceanic crust formed after rifting. A major criticism of the reconstruction is the overlap of Central America on to South America and absence of the Caribbean Sea. This must be viewed, however, in the light of our knowledge of the history of the opening of the Atlantic based, for the most part, on its

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