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Figure 9.32. Using Swiss-PdbViewer to compare homology model to template. Ramachandran diagrams are shown for (a) Human aquaporin 1 (PDB ID 1J4N) and (b) The model for canine aquaporin generated by ESyPred3D shown in Figure 9.31. Note the overall similarities between the range of values occupied and that most of the nonglycine residues outside the three heavily-populated parts of the diagram are common to both structures. These similarities, combined with absence of side-chain clashes, suggest that this model is structurally plausible.

TABLE 2 Comprison of MIR/NIR Roman Spectroscopic Techniques Spectroscopy Spectral range (cm 1) Signal intensity Microscopic analysis Fiber-optic interfacing Sampling through glass Qualitative application Quantitative application Instrument robustness Chemical Interpretation NIR 12,000 4,000 ++ No Yes Yes Yes Yes +++ Chemometrics IR 4,000 400 +++ Yes Yes (limited length) No Yes Dif cult + Direct Raman 4,000 50 + Yes Yes Yes Yes Yes ++ Direct

Frequency (MHz)





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Installation of antenna arrays for mobile communication systems (including GSM and third generation) and sonar, radar and biomedical applications involves the consideration of many factors, and ultimately compromises to meet both system performance and commercial cost imperatives. This section uses a mobile communications system to illustrate these factors. Physical constraints of a basestation (BS) antenna array are dependent upon the installation being considered. The three main types of BS installation are:

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A quality plan is required by the regulations governing medical devices (QSR) but can readily be adopted as a useful tool for pharmaceutical and biopharmaceutical manufacturing operations A quality plan is the documented plan and goals for enhancing and advancing the QMS It can provide the outline and requirements of the organization s purpose, mission, product, and business practices used to produce a quality product A quality plan can detail the processes that comprise the QMS, the maturity level required for each process, organizational structure, and other requirements needed to meet the organization s purpose Included in the quality plan are the elements of the business including location, size, products, and expectations It also includes its structure and support functions, values, and other attributes of the organization An annual quality plan can be the detailed execution plan of the organization s long-term quality vision for the QMS.

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It provides staff and management the outline and goals for improving the QMS It enables employees to see the big picture, how they t into the organization, and the organization s expectations Within the quality plan attributes of the QMS should be described, including functional management responsibility This then becomes the foundation for further de nition of processes, description of management review and responsibility, and continuous improvement programs The preparation of a quality plan begins de ning what is assumed to be known by all levels of the organization It is the mechanism for ensuring requirements are addressed and gaps in the organization do not exist A quality plan may outline the organization s long-term (several years) and short-term (annual) goals through a risk-based approach to improving product quality It is the foundation for the manufacturing structure and support processes.

A quality plan ensures integration of personnel, their quali cations, product requirements, quality management system, and regulatory and compliance infrastructure An example of an outline of a quality plan is in Table 4 Leadership review and approval of the quality plan is required to ensure that mission, scope, expectations, and division of labor in the organization is consistent and supported In larger organizations, site or suborganization-based quality plans can be designed to support the scaling of the QMS across all components of the enterprise The individual site plans provide focus on process challenges that are more critical than at other sites due to variations in business and compliance environments While the speci c plans emphasize goals based on site priorities, they also connect the members of an organization to the mission of the greater QMS, as shown in Figure 5 3343 Determining Process Resolution Requirements.

(14.20) (14.21)

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