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Polymer reagents, catalysts, and substrates have practical advantages compared to their small molecule analogs An insoluble polymer reagent, catalyst, or substrate can be easily separated from the other (ie, the small molecule) components of a reaction system by ltration This ease of separation allows the synthesis of high-purity products and the recovery of the polymeric species, with resulting economies Reactions with functional polymers are sometimes advantageously carried out in a manner similar to that for column chromatography The polymeric species is packed in a column and the small molecule species poured through the column Some of the more speci c details are described in Secs 9-12 through 9-14 When the polymer reagent, catalyst, or substrate is easily recoverable, it can be economically used in large excess to achieve high yields in a reaction.



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(F.5)

Small-molecule reagents, catalysts, or substrates that are highly reactive, toxic, or malodorous can be handled much more safely and easily in the form of the corresponding polymers Other advantages of functional polymers may arise from the enhancement of rate or equilibrium due to factors discussed in Sec 9-1 These factors may also lead to negative effects in some systems There are disadvantages that limit the commercial utilization of polymer reagents, catalysts, and substrates at this time Functional polymers are more expensive than their smallmolecule analogs Many applications that work well in the laboratory fail the economics of industrial use One needs large-scale uses where one or another of the advantages of functional polymers cannot be achieved by other means Filtration of a polymer reagent, catalyst, or substrate is often not easy.





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The Lorentzian representation and Cauchy's principal part can be obtained from another attempt of making (F.4) more mathematically correct. Instead of making the endpoints of the ill-defined integral finite, we can damp the oscillations of the exponential at infinity. Consider the integral

Fine particles slough off from larger beads or ground resin because of the stresses resulting from mechanical stirring or shaking These nes interfere with ltration by clogging the lters For a few functional polymers, the functional group(s) of importance may not be permanently anchored; in other words, the functionalization reaction is reversible This is the case with some polymer catalysts containing transition metal groups The transition metal components leach out with time Organic supports are of lesser stability than inorganic supports The advantages of functional polymers are best realized when used in two situations multistep sequential reactions and automated parallel combinatorial synthesis to produce libraries of compounds In both situations there is a large savings in the time and expense of carrying out the many chemical reactions and their corresponding handling and puri cation steps.

';(x)

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Insoluble polymer reagents, catalysts, and reagents have received the most attention, but there is increasing work with soluble polymer reagents, catalysts, and reagents [Bergbreiter, 2001, 2002; Osburn and Bergbreiter, 2001; Toy and Janda, 2000] Insoluble functional polymers have some de ciencies They are dif cult to characterize and monitoring of the progress of reaction is also dif cult Insoluble functional polymers often show low reactivity and altered selectivity (chemo-, regio-, and stereoselectivity compared to the corresponding small-molecule reactions) Soluble reagents, catalysts, and reagents are easy to characterize, and their chemical behavior is much closer to that of the small-molecule reactions This makes it easier to make the transition from small-molecule reactions to using soluble polymer reagents, catalysts, and reagents Poly(ethylene glycol) (PEG) is extensively used as a soluble polymer support It is a low molecular weight poly(ethylene oxide) with hydroxyl groups at both chain ends.

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i. 1 = - hm - - .

The terminal hydoxyl groups allow for attachment of a wide range of other functional groups that.

eik(x+i )

perform reagent, catalyst, and substrate functions. PEG is soluble in water and many organic solvents, but insoluble in hexane, ether, and cold isopropanol. Soluble polymer supports, like their insoluble counterparts, offer the advantage of ease of separation. After carrying out a chemical process, the polymer reagent, catalyst, or substrate can be isolated by adding a nonsolvent, for instance, by adding isopropanol for PEG supports.

(F.6)

9-12

A wide range of polymer reagents have been studied [Akelah and Sherrington, 1983; Blossey and Ford, 1989; Ford, 1986a; Kirschning et al., 2001]. The epoxidation of an alkene by a polymer peracid illustrates the use of a polymer reagent [Frechet and Haque, 1975]. Chloromethylated polystyrene is treated with potassium bicarbonate in dimethylsulfoxide to yield

The alternative more mathematically correct way of writing (F.4) is to rewrite the ill-defined integral in the last line of (F.4) as twice the real part of (F.6):

9-68

8(x)

the formylated derivative which is then oxidized to the peracid (Eq. 9-68). The polymer peracid is used to epoxidize an alkene by the scheme shown in Fig. 9-1. A mixture of the

= 2~ {';(x)} =

Fig. 9-1 Scheme for utilization of a polymer reagent. The epoxidation of an alkene by a polymer peracid.

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