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amounts in the polyphenols of red wine and grape seeds Sixty to seventy percent of the polyphenols are found in the seeds of the grapes184,185 Proanthocyanidins are believed to exhibit a wide range of biologic, pharmacologic, chemoprotective, and antioxidant activities186 ANTIOXIDANT ACTIVITY Various studies have reported on the potent antioxidative and free radical scavenging activities of proanthocyanidins187 191 Grape seed extract has been shown to be an even stronger scavenger of free radicals than vitamins C and E192 Dietary intake of grape seed proanthocyanidins (GSP) has been shown to inhibit UV-induced skin cancer in mice193 Mittal et al demonstrated that oral intake of GSP in SKH-1 hairless mice resulted in prevention of photocarcinogenesis with reduced tumor incidence, multiplicity, and size compared with non-GSP treated mice following a UVB-induced carcinogenesis protocol Biochemical analysis revealed that treatment of GSP in in vivo and in vitro systems significantly inhibited UVB- or Fe3 induced lipid peroxidation, suggesting a possible antioxidant mechanism of photoprotection by GSP193 In another study, investigators demonstrated that treatment of NHEK with GPS inhibited UVinduced oxidative stress by inhibiting UVB-induced H2O2, lipid peroxidation, protein oxidation, and DNA damage as well as scavenging hydroxyl radicals and superoxide anions in a cell-free system Moreover, GSP also inhibited UVBinduced depletion of antioxidant defense components, such as GPX, catalase, superoxide dismutase, and glutathione Treatment of NHEK with GSP further inhibited UVB-induced phosphorylation of ERK1/2, JNK, and p38 proteins of the MAPK family194 As UV-induced oxidative stress mediates activation of MAPK and NF- B signaling pathways, the same group further examined the effect of dietary GSP on these pathways and proved that GSP exhibits the ability to protect the skin from the adverse effects of UVB radiation via modulation of the MAPK and NF- B signaling pathways This provides a molecular basis for the photoprotective effects of grape seed extract in an in vivo animal model195 Dietary GSP was also shown to modulate UVB-induced immunosuppression by reducing the immunosuppressive cytokine IL-10 while enhancing the production of the immunostimulatory cytokine IL-12, suggesting this to be one of the possible mechanisms by which grape seed extract prevents photocarcinogenesis in mice196.

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PS (1) > function hello { "Hello world" } PS (2) > hello; hello; hello Hello world Hello world Hello world

1 4 1 6 z z + 2! 3!

But a function that writes only hello world isn t very useful. Let s personalize this a bit and add a parameter to the function. In fact, we don t have to do anything at all, because there is a default argument array that contains all of the arguments to the function. This default array is available in the variable $args. Here s a basic example:

PS (3) > function hello { "Hello there $args, how are you " } PS (4) > hello Bob Hello there Bob, how are you

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And so C e z dz = 0 Now let s try a different approach First we break up the integral into separate integrals along each of the curves I, II, and III:

This example uses string expansion to insert the value stored in $args into the string that is emitted from the hello function. Now let s see what happens with multiple arguments:

GRAPE SEED EXTRACT APPLICATIONS IN HUMANS Thus far, there are no comparable studies in humans Grape seed extract is included in topical cosmetic formulations with the intention of imparting an antiaging effect It is a popular ingredient in organic products However, additional studies are needed to further understand its effects on human skin when used topically

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Following the string expansion rules described in chapter 3, the values stored in $args get interpolated into the output string with each value separated by a space. Or, more specifically, separated by whatever is stored in the $OFS variable. So let s take one last variation on this example. We ll set $OFS in the function body with the aim of producing a more palatable output. We ll take advantage of the interactive nature of the PowerShell environment to enter this function over several lines:

PS (6) > function hello >> { >> $ofs="," >> "Hello there $args and how are you " >> } >> PS (7) > hello Bob Carol Ted Alice Hello there Bob,Carol,Ted,Alice and how are you

That s better. Now at least we have commas between the names. Let s try it again, with commas between the arguments:

PS >> >> >> >> (1) > function count-args { "`$args.count=" + $args.count "`$args[0].count=" + $args[0].count }

2 2 2

TABLE 34-2 Antioxidant Potency Composite Indexa, Based on the Ranking of Four Antioxidant Assaysb BEVERAGE Pomegranate juice Red wine Concord grape juice Blueberry juice Black cherry juice A a juice Cranberry juice Iced green tea Orange juice Iced white tea Apple juice Iced black tea

This function will display the number of arguments passed to it as well as the number of elements in the first argument. First we use it with three scalar arguments:

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