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ously wondered if their specialty had come to its end 37 Corticosteroids are known to suppress proinflammatory genes that encode cytokines, cell adhesion molecules, and other mediators that interfere with the inflammatory response38 They selectively induce annexin I, an antiinflammatory protein that physically interacts with and inhibits cytosolic phospholipase A2 (cPLA2 )39 By inhibiting this phospholipase they block the release of AA and its subsequent conversion to eicosanoids such as PGs, TXs, prostacyclins, and LTs40 A second antiinflammatory protein induced by corticosteroids is MAPK phosphatase-1 Bacteria, viruses, cytokines, and, interestingly, UV radiation are all examples of inflammatory signals that activate the MAPK cascades41 Finally, glucocorticoids also induce and antagonize NF- B, which is known to stimulate the transcription of COX-2, an enzyme essential for PG production42 Since some of the anti-inflammatory mechanisms of glucocorticoids are also involved in physiologic signaling rather than inflammatory signaling, the therapeutic effects of these drugs in inflammation are often accompanied by clinically significant side effects40 Therefore, although topical corticosteroids are generally well tolerated for short-term use on inflammatory skin diseases, longterm widespread use can result in serious cutaneous adverse effects that include: skin atrophy, hirsutism, folliculitis, acne, striae, telangiectasia, purpura, and changes in pigmentation43,44 Moreover, even more serious systemic side effects such as hypothalamic pituitary axis (HPA) suppression,45 hyperglycemia,46 avascular osteonecrosis,47 glaucoma,48 and posterior subcapsular cataracts49 have also been reported in association with the long-term use of topical corticosteroids

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[-Strict ]

In this trace mode, each statement executed by the interpreter will be displayed on the console as shown.

Figure 94 The rectangle in Fig 93 transformed by w = (1 + i) z It is rotated by /4 about the origin and lengths are increased by 2

PS (2) > 2+2 DEBUG: 1+ 2+2 4 PS (3) > $a=3 DEBUG: 1+ $a=3 PS (4) > pwd DEBUG: 1+ pwd Path ---C:\files

The debugging output is prefixed with the DEBUG: tag and is typically shown in a different color than normal text. Note that the entire script line is displayed. This means that if you have a loop all on one line, you ll see the line repeated:

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The medicinal use of sulfur dates back to the time of Hippocrates, who is believed to have mentioned its use for the treatment of plague67 It is currently found in many products including the spa waters and elegant products from the Vichy spa in France Most of what is known about sulfur was written decades ago, with moderate to little interest evinced in the recent literature Nevertheless, sulfur continues to be used throughout the world mainly to treat acne, seborrheic dermatitis, rosacea, scabies, and tinea versicolor68 Elemental sulfur (a yellow, nonmetallic element) and its various forms (eg, sulfides, sulfites, and mercaptans) are believed to have antimicrobial, antifungal, and antiparasitic properties Furthermore, sulfur-containing compounds have proved to be excellent anti-inflammatory agents 69 Interestingly, the action of sulfur in the skin depends on its direct interaction with the cutaneous surface; the smaller the particle size, the greater the area available for sulfur skin interaction and the greater the efficacy70 Two sulfur preparations are found as official formulations in the United States Pharmacopoeia: sublimed sulfur and precipitated sulfur Precipitated sulfur has a smaller particle size and therefore is superior in efficacy to sublimed sulfur; in fact, this is the type of sulfur most widely used

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If the transformation is of the form w = z + , the effect is to translate the region to the left or to the right by the magnitude of the real part of , and up or down by the magnitude of the imaginary part of Consider the transformation w = (1 + i ) z + 3 on the rectangular region shown in Fig 93 The effect of this transformation is to rst rotate and expand lengths, and then to translate along the real axis The points at the four corners of the rectangle are transformed according to (1, 0) (4, i ) (1, i ) (3, 2i ) (0, i ) (2, i ) (0, 0) (3, 0) The transformed rectangular region looks something like that in Fig 95 Now let s consider a square region in the z plane de ned by 0 x 1, 0 y 1 Consider the transformation w = z +1+ i All this does is shift the square over to the right one unit and up one unit This is illustrated in Fig 96

PS (5) > foreach ($i DEBUG: 1+ foreach DEBUG: 1+ foreach i is 1 DEBUG: 1+ foreach i is 2 DEBUG: 1+ foreach i is 3 in 1..3) {"i is $i"} ($i in 1..3) {"i is $i"} ($i in 1..3) {"i is $i"} ($i in 1..3) {"i is $i"} ($i in 1..3) {"i is $i"}

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