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receptors for vitamin D, estradiol, glucocorticoids, and thyroid hormone13 The retinoic acid receptor family is composed of two types of receptors, the RARs and the RXRs The RARs and the RXRs are divided into , , and subtypes The RAR , RAR , and RAR genes have been localized to chromosomes 17q21, 3p24, and 12q13, respectively, and the RXR , RXR , and RXR genes have been mapped to chromosomes 9q343, 6p213, and 1q22-23, respectively14 These receptors are able to regulate gene expression in two ways: (1) they induce gene expression by binding to specific DNA sequences known as retinoic acid responsive elements (RAREs), or (2) they inhibit gene expression by downregulating the actions of other transcription factors (such as AP-1 and NF-IL6) All the , , and subtypes exhibit distinct affinities for retinoic acid and show a characteristic tissue distribution For example, epidermis is a privileged tissue for the expression of RAR and RXR , the major isoforms of their respective families in this tissue, whereas RAR is ubiquitous In the skin, RAR is primarily found in the dermis, and it is also found in other body tissues7 Ninety percent of the RARs in the epidermis and cultured keratinocytes are



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Now write out the entire array along with the string [0] (remember, on the command line, strings don t need to be quoted).

PS (15) > write-host $a [0] 1 2 3 [0]

Frequently, in complex analysis we wish to consider a circular region in the complex plane We call such a region a disk Suppose that the radius of the disk is a If the points on the edge of the disk, that is, the points lying on the circular curve de ning the border of the disk are not included in the region of consideration, we say that the disk is open Consider a disk of radius one centered at the origin We indicate this by writing z <1 This is illustrated in Fig 26 If the disk of radius r is instead centered at a point a, then we would write z a <r





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Next, let s just write out the first element of the array:

PS (16) > write-host $a[0] 1

RAR , which is the receptor associated with terminal differentiation; therefore, this receptor is the target of the retinoids used in dermatology15 The interactions of the retinoid receptors among themselves and other receptors of the nuclear hormone superfamily are complex RARs are known to heterodimerize with RXR in order to interact with their RAREs and mediate classic retinoid activity and toxicity RXRs, however, are more promiscuous, heterodimerizing with several other members of the steroid receptor superfamily including peroxisome proliferator-activated receptors (PPAR), vitamin D receptors, thyroid hormone receptors, and a number of orphan receptors, such as LXR, PXR, and FXR16 The interactions of these receptors are being studied intensively; however, more research is necessary to fully delineate the mechanisms of action of retinoid agents

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You can see that the only difference between the first and second command lines is the presence of a space between the array variable and the opening square bracket. This is why spaces are not permitted in array indexing operations. The square bracket is used for wildcard expressions, and we don t want those confused with array indexing on the command line. From the syntax (and from previous examples), you can see that array indexing works on more than just variables. In fact, it can be applied to any expression that returns a value. Of course, because the precedence of the square brackets is high, you usually have to put the expression in parentheses. If you don t, you ll get an error, as in the following example.

Figure 26 The disk z < 1 is centered at the origin The boundary is indicated with a dashed line, which is sometimes done to indicate it is not included in the region of de nition

PS (1) > 1,2,3[0] Unable to index into an object of type System.Int32. At line:1 char:7 + 1,2,3[0 <<<< ]

The error occurred because, due to precedence rules, we were in effect trying to index into the scalar quantity 3 , which is not indexable. If we put the left value expression in parentheses, it works as desired.

For example: z 3 <5 describes a disk of radius ve centered at the point z = 3 This is shown in Fig 27 EXAMPLE 211 Compute lim(iz 1) / 2 in the open disk z < 3 z 3 SOLUTION Notice that the point z = 3 is on the boundary of the domain of the function Just plugging in we nd lim

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