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effects of topical estrogen on cutaneous wound healing in healthy elderly men and women after receiving punch biopsies and related these effects to the inflammatory response and local elastase levels (a matrix metalloproteinase known to be upregulated in chronic wounds); it was found that compared to placebo treatment, estrogen treatment increased the extent of wound healing in both elderly males and females 13 These authors further determined that estrogen treatment was associated with a decrease in wound elastase levels secondary to reduced neutrophil numbers and decreased fibronectin degradation Similarly, an observational study showed that HRT recipients are approximately 30% to 40% less likely to develop a venous leg ulcer or a pressure ulcer than nonrecipients 32 In contrast, androgens appear to prolong inflammation and inhibit wound healing 14,33,34 Estrogen also promotes wound healing by increasing tissue expression of vascular endothelial growth factor (VEGF), an effect that is antagonized by androgens; therefore, estrogen can promote neovascularization that is necessary for wound healing while androgens inhibit it14 As estrogen has a direct stimulatory role on dermal fibroblasts, it also affects scarring Aged skin is associated with a reduced rate of cutaneous wound healing and improved quality of scarring, while young skin heals quickly but often with thick, visible scars Keloids and hypertrophic scars are generally conditions of youth, owing to an increase in TGF- production by dermal fibroblasts, while scarless wound healing is a characteristic of fetal skin that, like aged skin, has lower levels of TGF- 35 As estrogen is known to increase TGF- , and is therefore profibrotic, antiestrogens such as tamoxifen have been shown to decrease TGF- levels,36,37 and are antifibrotic Therefore, tamoxifen or other estrogen receptor modulators may be useful in improving scar cosmesis



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Keep in mind is that we didn t really load the assembly again. Once an assembly has been loaded into a process, it can t be unloaded, so all this really did was verify that the assembly was loaded. There is something else to note. Even when we specify the full name of the assembly, we didn t have to tell the system were to find the file. This is because the assembly has been GACed ; that is, it has been added to the Global Assembly Cache (GAC). The GAC is a location defined by the system for where it should look up assemblies by default. Sometimes, however, the assembly that you re loading hasn t been GAC ed. In this case, we can load it by specifying the path to the file. If you look at the output, we can see where this file is stored. Let s load it one more time using the file name:

PS >> >> >> PS (6) > $name = "C:\WINDOWS\assembly\GAC_MSIL\" + "System.Windows.Forms\2.0.0.0__b77a5c561934e089\" + "System.Windows.Forms.dll" (7) > [reflection.assembly]::LoadFrom($name) Version ------v2.0.50727 Location -------C:\WINDOWS\assembly\GAC_MSIL\System.Win...

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At this point, we ve covered the most important parts of loading assemblies that we need to know to work with PowerShell. This is another tip of the iceberg topics where we ve only covered the minimum necessary. For more details read the Microsoft Developer Network documentation at http://msdn.microsoft.com. We ve mastered the arcane incantations needed to load assemblies. So what s next Obviously, now that we have the assembly loaded, we need to be able to find out what types it contains. 11.1.3 Finding types There are a lot of types with a lot of members loaded into the PowerShell process. To get the list of what s available, we simply ask the system to tell us. To start, we need to get a list of the assemblies that are loaded. A handy function that returns that list is shown in listing 11.1.

An unproven conjecture by Riemann is that all of the zeros of ( z ) can be found on the line Re( z ) = 1/ 2 We show a plot of | (1/ 2 + iy) | in Fig 117, where you can see the zeros of the function for 0 y 50 The real and imaginary parts of (1/ 2 + iy) are illustrated in Figs 118 and 119, respectively While Riemann s conjecture has yet to be proven, Hardy demonstrated that there are in nitely many zeros along the line Re( z ) = 1/ 2 In Fig 1110, we consider the Riemann zeta function for real argument A plot of ( x ) shows an asymptote at x = 1 where the function blows up Like the gamma function, the Riemann zeta function has a representation in terms of in nite products This is given by 1 1 1 1 = 1 z 1 z 1 z 2 3 5 (z) 1 = 1 z p p (1122)

function Get-Assemblies { [AppDomain]::CurrentDomain.GetAssemblies() }

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