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available in the United States for medical use Botox Cosmetic (Allergan Inc, Irvine, CA) and Dysport (Ipsen Products, Maidenhead, Berkshire, UK) are both formed from serotype A, which functions by cleaving the SNAP-25 protein, a component of the SNARE (Soluble N-ethylmaleamide-sensitive factor Attachment protein Receptor) complex (Box 22-2) The presence of an intact SNARE complex, composed of synaptobrevin, SNAP-25, and syntaxin, is necessary for vesicles containing ACh to fuse with the cell membrane and to release ACh into the neuromuscular junction (Fig 22-1) BTX-B, now available in the United States as Myobloc (known as Neurobloc in Europe), cleaves synaptobrevin, thus preventing the release of ACh



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Notes: The switch statement allows you to select alternatives based on a set of clauses. It combines features of both the conditional and looping constructs. An example of a switch statement looks like

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switch -regex -casesensitive (get-childitem | sort length) { "^5" {"length for $_ started with 5" ; continue} { $_.length > 20000 } {"length of $_ is greater than 20000"} default {"Didn't match anything else..."} }

<foreachStatementRule> = <LoopLabelToken>{0 |1} 'foreach' '(' <variableToken> 'in' <pipelineRule> ')' <statementBlockRule>

SOLUTION We use the series representation of the cosine function: 1 2

Notes: The foreach statement loops over an enumerable collection. An example of a foreach statement is:

Acetylcholine (ACh) is the neurotransmitter associated with induction of musFIGURE 22-1 Botulinum toxins inhibit the release of acetylcholine into the neuromuscular junction

foreach ($i in get-childitem | sort-object length) { $i $sum += $i.length }

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Also note that there is a Foreach-Object cmdlet that can be used to process objects one element at a time. While this cmdlet is similar to the foreach statement, it is not part of the language. C.2.5 The for and while statements

<forWhileStatementRule> = <LoopLabelToken>{0 |1} 'while' '(' <pipelineRule> ')' <statementBlockRule> | <LoopLabelToken>{0 |1} 'for' '(' <pipelineRule>{0 |1} ';' <pipelineRule>{0 |1} ';' <pipelineRule>{0 |1} ')' <statementBlockRule>

while ($i -lt 100) { echo i is $i $i += 1 }

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for ($i=0; $i -lt 10; $i += 1) { echo i is $i }

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BOX 22-2 Composition of Botulinum Toxin BTX is composed of three domains: the binding domain, the translocation domain, and the enzymatic domain The binding domain is responsible for attaching to the presynaptic nerve terminal (These receptors are speci c to each BTX serotype and the serotypes do not bind to each other s acceptors) Binding of the toxin initiates endocytosis and internalization of the molecule Once inside the endosome, the acidic environment is believed to create a change in the conformation of the translocation domain of the toxin that allows the light chain to cross the membrane of the endosome and enter the cytosol2 Once released into the cytosol, the enzymatic domain residing in the light chain cleaves a protein in the SNARE complex that inactivates this complex, preventing the fusion of ACh vesicles and blocking release of ACh into the synaptic cleft The speci c cleaved SNARE complex protein depends on the BTX serotype BTX-A cleaves the SNAP-25 molecule at the peptide bond between glutamine 197 and arginine 198 and BTX-B cleaves synaptobrevin between the amino acid residues glutamine 76 and phenylalanine 773 Interestingly, tetanus toxin also cleaves synaptobrevin, but uses a different enzyme

C.2.6

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<doWhileStatementRule> = <LoopLabelToken>{0 |1} 'do' <statementBlockRule> ['while' | 'until'] '('<pipelineRule> ')'

Notes: Here is an example of a do/while statement:

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do { write-host $i $i += 1 } while ($i -lt 100)

the neck, which leads to a condition commonly known as turkey neck Some practitioners have also obtained satisfactory results in treating the signs of aging in the lower face9,10 New indications are frequently reported

And an example of a do/until statement:

do { write-host $i $i += 1 } until ($i -ge 100)

1 n = 0 2

C.2.7

trap { ... }

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