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Con ict Resolution. It is quite possible, especially in a large and complex knowledge base containing hundreds of rules and many different interactions among the rules (oftentimes unforeseen by the designer), for an expert system to arrive at two con icting recommendations. In our stock-picking example, the expert system could make two con icting recommendations based on the following two initial facts:

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manager/system manager: an IT person or a laboratory person The other concerns whether to build or buy a new LIMS Advocates for building a new LIMS usually state that their laboratory is so unique that they can t use a commercial LIMS Very few laboratories are unique it is their products that are unique Laboratories generally work in the same way: Laboratories get a sample from somewhere This may be external or internal; the latter including, for example, raw material, R&D, production, or study This may be split into several samples to be analyzed Analyses are done in various laboratories based on sites, laboratory type, and projects/products The analytical methods may be manual or instrumental The manual ones may include what the sample looks like or smells like The instrumental ones may be virtually everything else that uses one or more instruments to obtain results.





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The results are often compared to speci cations to see that the sample conforms A manager approves or authorizes the results before they are reported, often on a Certi cate of Analysis (CoA) A typical information ow through a LIMS is shown in Figure 181 The only thing that is unique in the laboratory is that each one has its own types of samples, and its own set of instruments, analytical methods, and speci cations Advocates also say that they can build a LIMS in a few months in an Oracle, Access, or SQL database This will be completely tailored to their needs and it will be much cheaper than a commercial offering Let us discuss these statements It may be possible to build LIMS in a few months.

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To do so requires that there is a very, very good User Requirements Speci cation that covers everything that the laboratory ever does and will do in the future Few people are able to write such a speci cation, especially to include how they will work in the future There is a very high risk that a home-made LIMS will not be exible enough to allow for future changes There is a greater chance that programming it will actually take a lot longer than a few months By then, the users will have found many more things that should be included in the system, and these requirements will be added to the initial ones We will then get what is generally called scope creep The result will invariably be that the project will take longer than anticipated.

A commercial LIMS includes several decenniums or even centennials of manworking days in its planning, programming, and testing If a programmer is used to prepare the LIMS, he will probably not know enough about laboratories to even ask the right questions when he is in doubt If a laboratory person is used, he will probably not know enough about programming to do a good job And unless either of these people is highly skilled in Quality Assurance, the chances are that they will program without producing enough documentation, such as a Requirements Speci cation, other speci cations and plans, test plans, testing, reports, and so on In any case, the laboratory will de nitely have GAMP [1] Category 5 software, which will be frowned upon and scrutinized by the FDA and European authorities and probably not pass the inspection Back to square one.

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