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You can create custom symbols in SolidWorks, but creating them may not be as simple as you expect. In the lang\english subfolder of the SolidWorks installation directory is a file called Gtol.sym. This file stores the representations of all of the SolidWorks symbols. It is also where you can create symbols of your own. You can edit the file in Notepad. As a warning, unless you enjoy writing scripts for the command line, or you are a fan of DOS 5.0, then you may not want to create custom symbol projects. The format for creating symbols is simple enough, but it is what you might call somewhat arcane. It is effective at creating line-art symbols that can be used with text and can even be used to contain text. If you are a little inventive with this, then you can create interesting shapes that integrate with your notes and dimensions. Keep in mind that this topic does not appear in the Help files, but all of the instructions you need are inside the file itself. You may have to experiment a little to discover what the rules are in terms of making shapes outside of the limits of the 1X1 matrix. It is probably easier to create the geometry using Blocks functionality, but blocks cannot be inserted into text notes as easily as symbols.



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Shef eld, VC, et al, A Collection of Tri- and Tetranucleotide Repeat Markers Used to Generate High Quality, High Resolution Human Genome-Wide Linkage Maps, Hum Mol Genet, 4, 1837 1844 (1995) Shen, M-J, et al, Nonconservative Amino Acid Substitutions Exist at Polymorphic Frequency in DNA Repair Genes in Healthy Humans, Cancer Res, 58, 604 608 (1998) Shi, MM, et al, Pharmacogenetic Application in Drug Development and Clinical Trials, Drug Metab Dispos, 29, 591 595 (2001) Sorbi, S, et al, Genetic Risk Factors in Familial Alzheimer s Disease, Mech Ageing Dev, 122, 1951 1960 (2001) Strausberg, RL, et al, The Cancer Genome Anatomy Project: Building An Annotated Gene Index, Trends Genet, 16, 103 106 (2000) Tavtigian, SV, et al.





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espite all the new security features of Windows Vista and all the safety precautions you can use during your computing activities, you might still encounter situations that require additional preemptive and post-emptive measures. For example, if you encounter a power outage before you can save an important file you have been working on diligently for the past three hours, you want to make sure that you can retrieve as much of this document as you can after your computer is up again.

The generic pattern database, sometimes called the dynamic-diamond pattern, illustrated in Figure 1-2, is sometimes used as an OO DBMS physical design within a RDBMS product. This design can be useful when applications require dynamic attributes. A manufacturing materialspecifications system, for example, would require different attributes for nearly every material type. To further complicate matters, the attributes that are tracked frequently change depending on the Total Quality Management (TQM) or ISO 9000 process within the company. A purely relational database might use an entity for each material type, requiring constant schema changes to keep current with the material tracking requirements.

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The ACE inhibitors enalapril,42 spirapril, and quinapril from competing laboratories illustrate the wide diversity of structural modi cations that are compatible with this activity. Note, however, that all these compounds retain a similar sequence from the ring nitrogen on. Close to twenty discrete chemical entities have subsequently been assigned nonproprietary names. No fewer than fteen of those have been approved for use in the United States. Scientists at Norwich Eaton had also focused on the renin angiotensin system as a means of developing antihypertensive agents.46 Instead of seeking ACE inhibitors they set out to nd a compound that would antagonize the action of angiotensin II itself by binding with its receptor. This, it was hoped, would inhibit the vasoconstricting action of angiotensin II. By serial substitution of each of the amino acids in the natural substance they developed the antagonist saralasin. The fact that this drug was a peptide precluded widespread use. It was, as expected, not active orally and was quickly metabolized. It does, however, have occasional use by infusion to treat emergency hypertension. Scientists at the Du Pont Merck laboratories, in 1990, discovered a small synthetic molecule that acted as an angiotensin antagonist.47 The compound, later named losartan, had much the same activity as saralasin, although its chemical structure differed signi cantly from the peptide. One can safely assume that it interacts with the same receptor. The ve-membered ring with four nitrogen atoms, a tetrazole, serves the same function as the terminal carboxylic acid in saralasin. The drug offers advantages over the ACE inhibitors as it does not interfere with other targets for converting the enzyme. The discovery was followed relatively soon by angiotensin receptor antagonists from competing rms, eight of which have nonproprietary names and six of which are available in the United States.

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