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The FDA requires pharmaceutical industries to establish a stability testing program for each drug product [1 3]. Matthews [4] reviews the regulatory situation in Europe. The purpose of the stability program is to design the appropriate procedure to extract the assay data and calculate the shelf life to determine the expiration date of a drug product. The program should be described in a written protocol including all the requirements established by the regulation. The FDA establishes that the requirements to assess stability are the following [1]: 1. A sample size and test intervals for each attribute to be tested should be speci ed based on statistical rationale. 2. The storage conditions for the samples should be speci ed. The storage conditions should be the same as those speci ed in the drug product labeling. 3. All test methods used for each of the drug product attributes need to be quali ed to demonstrate adequacy and reliability. 4. The stability samples should be stored in the same packaging con guration used for the nal drug product to be marketed. 5. If the drug product needs to be reconstituted, testing of the drug product before and after reconstitution should be provided. 6. The number of batches to be used for the stability program for a new drug product is at least three. Different batches of the drug substance should be used. 7. The pharmaceutical industry should maintain records for all data, protocols, and reports related to the stability program. 7.2.1.3 Stability and Shelf Life



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Another choice is to change the global linetype scale, which affects all noncontinuous linetypes in your drawing. AutoCAD and AutoCAD LT multiply the linetype definition by the global linetype scale to calculate the length of each repetition of the linetype: Linetype scales larger than 1 result in longer sections and fewer repetitions of the linetype definition per unit. Linetype scales smaller than 1 result in shorter sections and more repetitions of the linetype definition per unit. When you change the linetype scale, the drawing regenerates to change all of the linetypes. Figure 11-25 shows three versions of a drawing with linetypes at linetype scales of 0.5, 1, and 2. As you can see, a scale of 2 is too large and a scale of 0.5 is too small. A scale of 1 is just right. (Goldilocks would have been happy with it.)

Figure 24.17 Tandem dual-system backup schema with two hardware pieces: gateway hardware and ePR server hardware. Each hardware piece has two softwares ePR server software, and gateway software and a tandem database with hard drive for data and metadata archive.

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4. The next step in the installation is the security settings screen where you can choose to turn on or off the Windows Update mechanism. It s recommended that you enable this so that your copy of Windows is always kept up-to-date automatically. (See Figure 17-41.) Click Next to continue. 5. Now the Windows Setup Wizard will check to see if you are connected to the Internet and asks for some basic information. See Figures 17-42 and 17-43. Enter this and click Next. Alternatively, you can choose to Skip and enter the details later.

Common code stored in the external script library actually includes more than just the code created when you use Actions. It also includes the code from some Smart Objects such as the URL pop-up menu and rollovers. In addition, it stores the code you generate when you animate a floating box and when you use a component on a page.

Up to this point, we ve looked at tools in Reader for views and displays, navigation, finding and searching text, and Web links. As you examine the Reader Command bar, notice that only three editing tools are available. Reader, as a viewer, cannot create or modify text. You can, however, select both text and graphics in Reader. The three tools that appear as editing tools are the Text Select tool, the Column Select tool, and the Graphics Select tool. When the tools are expanded, they appear, as shown in Figure 3-23.

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Go ahead and put the motherboard down in or near its intended location. At this point, it s probably a good idea to check your CPU cooler to make sure you don t have clearance issues. That means unpacking that device and simply placing it on top of the CPU socket. If this raises concerns about possible damage to the socket, cut a small piece of cardboard to cushion the cooler while protecting both cooler and socket from each other. Next, eyeball the top of the cooler (or fan, since many have fans installed on top) vis- -vis the top or side panel of your case. Your goal is to determine if the case can accommodate the cooler once it s installed. For example, despite a great big case for our P4 build, we still had to switch from one enormous (but incredibly quiet and efficient) CPU cooler to a smaller model when we realized our initial choice was tall enough to prevent us from replacing the side panel had it been installed.

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