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shown in Figure 9.9, where it is evident that when the ruling is at the marginal focus, the only closed-loop fringes are inside the mirror and the outer one closes near the edge of the mirror. It is also interesting to see that much information about the center of the mirror is lost when the fringes are curved, as at the paraxial focus. Therefore, to obtain the maximum information, the Ronchigram should be taken at the paraxial focus if K > 0 or at the end of the caustic if K < 0. 9.2.3. Null Ronchi Rulings We have shown that, when the surface under test is aspherical, the Ronchi fringes are not straight but curved. The surface errors can then be computed from the deviations of the fringes from the desired shape. This procedure can give very good results when the data are processed in a computer, as will be shown in Section 9.3. If a computer is not used, it is easier for a technician to detect deviations from a straight line than from a curved line. Also, when the fringes are curved, the diffraction effects tend to diffuse the fringes, making the measurements even more dif cult. These disadvantages can be overcome by means of a special kind of Ronchi ruling with curved lines, the curvature of which compensates for the asphericity of the surface in order to produce straight fringes of constant widths. This idea was rst qualitatively suggested by Pastor (1969) and was later developed quantitatively by Popov (1972) and independentely by Malacara and Cornejo (1974c) using a ray-tracing program an then solving ve linear equations. An approximate method to produced these null Ronchi rulings for paraboloids was devised by



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uid, pH, ow rate, or ltration It was recommended that if diazepam were to be infused, it should be diluted to at least 1 : 10 dilution in glass intravenous bottles and administered through plastic administration sets not having plastic burette chambers Inline lters (045 m) may be used without loss of potency [119] Similar studies were carried out by Morris [120] It was found that diazepam injection, in dilutions of 10 mg/dL or greater, was visually compatible and chemically stable in dextrose 5% in water, Ringer s injection, lactated Ringer s injection, and 09% sodium chloride in glass intravenous bottles when administered within 24 h However, the same type of study carried out in plastic intravenous bags instead of glass bottles showed that the solutions had a potency loss of greater than 24% within 30 min after dilution.





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Method relies on subject s memory Single 24-hour recall may not be representative of habitual intake; may be useful for group studies

The percentage of diazepam lost from solution increased with increase in concentration and time [121] Injectable lyophilized drug products are often presented in vials The rubber stopper forms a critical barrier: Protection of the product against moisture or oxygen is strongly dependent upon the quality and functioning of this barrier In fact, it has been reported that rubber not only is a barrier against moisture but also can be a source of water [122] Studies have been carried out to investigate the speed of water uptake, the saturation, and nally the permeability of different types of rubber closures with a view to understanding the fundamental mechanisms which determine the barrier quality and obtaining the easy method to discriminate between different rubbers.

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Thirteen-millimeter closures of the same dimensions were used: the Helvoet FM 157 (grey) and FM 257 (grey); the Pharma Gummi PH 701/45 (red), PH 21/50 (red), and PH 4104/40 (grey); and the West Company W888 (grey) All rubbers were of the bromobutyl rubber type, with the exception of W888, which consists of a halobutyl/ polyisoprene blend It was found that permeation through the closures is highly unpredictable owing to the concentration dependency of the diffusion coef cient D, which increases strongly with increasing RH It was indicated that new types of rubbers could be evaluated with respect to their barrier properties by means of the absorption pro les under stress conditions such as 40 C 95% RH Thus one does not require to make a selection on the basis of laborious permeation experiments [123] 7345 Container Extractables and Leachables and Drug Product Stability.

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Proof. By Theorem C.2, the matrix V is nonsingular only if it is positive definite. Therefore, if it is not positive definite, it is singular. rn

Your next step is to liberate the motherboard from its packaging. Here again, you ll want to find and set aside any manuals and software you find, as well as cables, fasteners, and other ancillary parts. That said, if your mobo includes a CPU cooler amidst its treasures, put the cooler somewhere safe because it s probably too big to fit inside your hardware Ziploc (unless you re building a Pentium M system).

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