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just use headsets where the antenna is not right next to their head But with millions of cell phone users in the United States, the controversy will not disappear Then there s the story of Lotronex It breaks all the rules of Type I and II Lotronex is the GlaxoSmithKline drug for irritable bowel syndrome, or IBS a gastrointestinal condition, more common in women than men, that causes abdominal pain, diarrhea, and constipation In November 2000, less than 10 months after it was approved, Lotronex was taken off the market because it was linked to five deaths and scores more cases of potentially fatal colitis, severe constipation, hospitalization, and bowel surgeries For that reason, it was among the drugs profiled in the Pulitzer Prize winning Los Angeles Times series about the spate of FDA withdrawals.



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This was also one of the cases where a member of an advisory committee had a controversial relationship with the drug sponsor So it s a classic Type I, a clear-cut case where a drug caused side effects worse than the condition it treated, and with some industry hanky-panky to boot The withdrawal in November 2000 should have been the end of the story Yet one and a half years later, flooded with letters, e-mails, and phone calls from thousands of patients demanding the drug, the FDA let Lotronex back on the market The agency added some requirements before prescriptions could be filled, similar to the kind levied on thalidomide and Accutane doctors must get special training from the manufacturer, explain the risks to patients, and report serious adverse effects to either the FDA or GlaxoSmithKline Also, all prescriptions must have special stickers.





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But the agency rejected the protests of the watchdog group Public Citizen that the new safeguards were not strong enough The IBS patients insisted that Lotronex was the only treatment that worked for them, side effects or not And they won..

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Figure 30-1: Permalinks, usually located near the end of articles, provide a unique URL to reference the article.

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do)(,)= b(x)

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Log of viscosity (Pa s) 22 23 24

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(A.3)

Thus the probability that none of the points except the original code point leading to y is a codeword approaches 1, so that the probability of decoding error - due to multiple codewords mapping to a single received vector - approaches 0. We remark that if the average of an ensemble approaches zero, then there are elements in the ensemble that must approach 0. Thus there are codes (not randomly selected) for which the probability of error approaches zero as n + 00. There are two other ways of viewing the coding rate requirement. The 2nH(YIX) typical sequences resulting from transmitting a vector x must partition the 2"*(') typical output sequences, so that each observed output sequence can be attributed to a unique input sequence. The number of subsets in this partition is

Some of these illusions can be found here: http://www.lottolab.org/.

Semaphores, introduced by Dijkstra (1968), were one of the first mechanisms proposed to deal with inter-process synchronization problems. semaphore S is A an integer variablethat can take only non-negative values. Once been given S has an initial value, the only operations permitted are up(s) and down(s~ S on defined as follows:

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