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In order for a process on one host to send a message to a process on another host, the sending process must identify the receiving process To identify the receiving process, one must typically specify two pieces of information: (i) the name or address of the host machine, and (ii) an identifier that specifies the identity of the receiving process on the destination host Let us first consider host addresses In Internet applications, the destination host is specified by its IP address We will discuss IP addresses in great detail in 4 For now, it suffices to know that the IP address is a 32-bit quantity that uniquely identifies the end-system (more precisely, it uniquely identifies the interface that connects that host to the Internet) Since the IP address of any end system connected to the public Internet must be globally unique, the assignment of IP addresses must be carefully managed, as discussed in section 44 ATM networks have a different addressing standard The ITU-T has specified telephone number-like addresses, called E164 addresses [ITU 1997], for use in public ATM networks E164 address consist of between seven and 15 digits, with each digit encoded as a byte (yielding an address of between 56 and 120 bits in length) The assignment of these address is carefully managed by country- or region-specific standards bodies; in the United States, the American National Standards Institute (ANSI) provides this address registration service We will not cover ATM end-system addressing in depth in this book; see [Fritz 1997, Cisco 1999] for more details In addition to knowing the address of the end system to which a message is destined, a sending application must also specify information that will allow the receiving end system to direct the message to the appropriate process on that system A receive-side port number serves this purpose in the Internet Popular application-layer protocols have been assigned specific port numbers For example, a Web server process (which uses the HTTP protocol) is identified by port number 80 A mail server (using the SMTP) protocol is identified by port number 25 A list of well-known port numbers for all Internet standard protocols can be found in [RTC 1700] When a developer creates a new network application, the application must be assigned a new port number.



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Before we begin a more detailed study of application-layer protocols, it is useful to discuss the notion of a user agent The user agent is an interface between the user and the network application For example,





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The second step is a site-speci c transportation of the drug, meaning that the drug-loaded BCP micelle should be selectively captured by the target (pathological sites) The third step is that once arrived on the target the BCP micelle opens the door to allow the drug to be released While the stable encapsulation of drug is crucial for giving the nanocarrier the time required to ferry the drug to the target, it could also render the drug release on the target more dif cult at a later time For each of the three steps, there has been much research effort aimed at developing effective strategies For the stable encapsulation, the crosslinking of BCP micelles is useful to provide the structural integrity and to slow down the leakage of the drug through crosslinked polymer chains (Thurmond et al, 1996).

file:///D|/Downloads/Livros/computa o/Computer%20Netwpproach%20Featuring%20the%20Internet/client_serverhtm (4 of 10)20/11/2004 15:51:50

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For the sitespeci c transportation, the functionalization of the micelle shell with a targeting ligand that can be recognized by a receptor highly exposed by the target remains the most appealing approach (Nasongkla et al, 2006) Finally, to release the drug quickly or in a controlled fashion after the micelle arrives on the target, the micelle should be structurally disrupted To this regard, a large number of BCP micelles have been designed to be able to react to an external stimulus, most of which are sensitive to pH change (Bellomo et al, 2004; Bae et al, 2003; Gillies and Frechet, 2003) This exploits the fact that tumor tissues are known to be slightly acidic (pH B68) and the endosomal and lysosomal compartments of cells have even lower pH (pH B5 6) with respect to the physiological pH 74 (Haag, 2004; Gillies and Frechet, 2003).

Fault Tree Analysis (FTA)

consider the Web For this application, the user agent is a browser such as Netscape Navigator or Microsoft Explorer The browser allows a user to view Web pages, to navigate in the Web, to provide input to forms, to interact with Java applets, etc The browser also implements the client side of the HTTP protocol Thus, when activated, the browser is a process that, along with providing an interface to the user, sends messages into a socket As an another example, consider the electronic mail application In this case, the user agent is a "mail reader" that allows a user to compose and read messages Many companies market mail readers (eg, Eudora, Netscape Messenger) with a graphical user interface that can run on PCs, Macs and workstations Mail readers running on PCs also implement the client side of application layer protocols; typically they implement the client side of SMTP for sending mail and the client side of a mail retrieval protocol, such as POP3 or IMAP (see section 24), for receiving mail

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