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BOX 1-1 1,25-Dihydroxyvitamin D3 [1,25(OH)2D3] stimulates differentiation and prohibits proliferation of the keratinocytes It exerts its effects via the nuclear hormone receptor known as vitamin D receptor (VDR) VDR operates with the aid of coactivator complexes There are two known coactivator complexes: vitamin D interacting protein complex (DRIP) and the p160 steroid receptor coactivator family (SRC/p160) It has been proposed that the DRIP mediator complex is involved in proliferation and early differentiation while the SRC/p160 complex is engaged in advanced differentiation11 The vitamin D receptors of undifferentiated keratinocytes bind to the DRIP complex, inducing early differentiation markers of K1 and K1012 The DRIP complex on the vitamin D receptor is then replaced by the SRC complex The SRC complex induces gene transcription for advanced differentiation, which occurs with laggrin and loricrin12 The replacement of the DRIP complex with the SRC complex on the vitamin D receptor is believed to be necessary for keratinocyte differentiation It is important to realize that vitamin D levels are lower in older people and that this reduction may play a role in the slower wound healing characteristic in the elderly



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DEBUG: ParameterBinding Information: 0 : Parameter [Path] PIPELINE INPUT ValueFromPipeline NO COERCION

This transformation has a pole located at the point z = d /c We are free to pick a point on the unit circle to map to the pole, so we choose z = 1 With this choice we have the freedom to x c and d, so we choose c = 1, d = 1 So Tz = az + b z 1

This is the first step in matching the parameter; if the parameter type exactly matches, then binding proceeds immediately.

DEBUG: ParameterBinding Information: 0 : BIND arg [c:\] to parameter [Path] DEBUG: ParameterBinding Information: 0 : Binding collection parameter Path: argument type [String], parameter type [System.String[]], collection type Array, element type [System.String], no coerceElementType





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In this case, the target type is a collection, but the element type of the collection matches the pipeline object, so the interpreter will wrap the pipeline object in an array so the binding can succeed.

Second, we need to pick a point z on the unit circle such that Tz = 0 We have already used the point z = 1, so we choose z = 1 This forces us to take a = b since Tz = 0 when z = 1 We can choose a = 1 giving us the transformation Tz = z +1 z 1

threonine kinase receptor TGF- 1 and TGF- 2 are present in small amounts in the keratinocytes The presence of calcium, phorbol esters, as well as TGF- itself increases the epidermal TGF- level and promotes differentiation23 TGF- has also been proven to have a role in scarring, and antibodies to this factor have been shown to decrease the inflammatory response in wounds and reduce scarring24, 25

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DEBUG: ParameterBinding Information: 0 : with element type [System.String] and 1 elements DEBUG: ParameterBinding Information: 0 : String is not IList, treating this as scalar DEBUG: ParameterBinding Information: 0 : element of type String to array position 0 DEBUG: ParameterBinding Information: 0 : [System.String[]] to param [Path] SUCCESSFUL

At this point, we ve bound the -path parameter. Let s check the remaining parameters that can take their values from the pipeline.

Now we can see how the transformation maps the rest of the unit disk The simplest point to check is the point z = 0 at the center of the disk We have Tz(0) = 0 +1 = 1 0 1

DEBUG: ParameterBinding Information: 0 : Parameter [Credential] PIPELINE INPUT ValueFromPipelineByPropertyName NO COERCION DEBUG: ParameterBinding Information: 0 : Parameter [Credential] PIPELINE INPUT ValueFromPipelineByPropertyName WITH COERCION

Nothing was bound at this point, so the last thing to do is check to make sure that all mandatory parameters for this cmdlet are now bound. If there were an unbound mandatory parameter, a non-fatal error would be generated and an error record would be written to the output pipe. Note how this is different from the command-line parameters. In that case, it s a fatal error; there s no way to continue. For the pipeline parameter, even if the current object doesn t result in all parameters being bound successfully, the next pipeline object may succeed. This is why pipeline binding failures are non-terminating and command-line binding failures are terminating.

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