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Rough, dry skin, mottled pigmentation, and wrinkling epitomize the clinical appearance of photoaging Extensive or severe photodamage can also be a precursor to skin cancer Despite increasing awareness of the risks of prolonged sun exposure, too many people remain unaware that the proverbial healthy tan is, in fact, evidence of photodamage and indicative of premature aging It is incumbent upon the dermatologist to educate patients on the ravages of the sun, the importance of sun avoidance and sunprotective behavior, and, as always, tailor treatments to individual patient needs

Point helper function function point ($x,$y) { New-Object Drawing.Point $x,$y }



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[reflection.assembly]::LoadWithPartialName( "System.Drawing") > $null [reflection.assembly]::LoadWithPartialName( "System.Windows.Forms") > $null

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$form = New-Object Windows.Forms.Form $form.Text = "Pick OK or Cancel" $form.Size = point 400 200 $label = New-Object Windows.Forms.Label $label.Text = $question $label.Location = point 50 50 $label.Size = point 350 50 $label.Anchor="top"

$ok = New-Object Windows.Forms.Button $ok.text="OK" $ok.Location = point 50 120 $ok.Anchor="bottom,left" $ok.add_click({ $form.DialogResult = "OK" $form.close() }) $cancel = New-Object Windows.Forms.Button $cancel.text="Cancel" $cancel.Location = point 275 120 $cancel.Anchor="bottom,right" $cancel.add_click({ $form.DialogResult = "Cancel" $form.close() })





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Growth factors can be classified into two groups: proliferative and differentiative factors Proliferative factors engender more DNA synthesis and result in proliferation of the cells Differentiative factors inhibit the production of DNA and suppress growth, thereby resulting in differentiation of the keratinocytes Epidermal growth factor (EGF) is one of the integral chemokines in the regulation of growth in human cells It binds to the epidermal growth factor receptor (EGFR) located on the basal and suprabasal cells in the epidermis and activates tyrosine kinase activity, which ultimately results in proliferation of the cells19 Keratinocyte growth factor (KGF), a member of the fibroblast growth factor family, also has a proliferative effect via the tyrosine kinase receptor on epidermal cells20 It has been shown that KGF contributes to and enhances wound healing21 In addition, KGF has been demonstrated to enhance hyaluronan synthesis in the keratinocytes22 Other important growth factors include the polypeptide transforming growth factors, which consist of two types: Transforming growth factor alpha (TGF- ) and transforming growth factor beta (TGF- ) They differ in both configuration and function TGF- is a proliferative factor, similar to EGF, and works by stimulating a tyrosine kinase response TGF- , which includes three subtypes (1 3), is a differentiative factor with a serine/

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$form.controls.addRange(($label,$ok,$cancel)) $form.Add_Shown({$form.Activate()}) $form.ShowDialog() }

This function takes one parameter B the question to ask with a default When setting size and location of controls on the form, we need to use point objects, so we ll create a local helper function C to simplify things We need to load both the Windows Forms assembly D and the Drawing assembly E so we can create an instance of the point class Although the classes defined in the forms library refer to the classes in the Drawing library, PowerShell will only find types in the explicitly loaded assemblies As in the previous example, we create the top-level form and set the caption, but this time, we re also setting the size of the form Next we create the label F, setting both the size and the location.

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We also set the Anchor property to top; this tells the layout manager to keep the label control anchored to the top of the form control No matter what the size of the control is, the label will always stay the same distance from the top of the form Then we create the OK button G, setting the caption and location Again, we re using the Anchor property to tell the layout manager to maintain the button s position relative to the bottom and left edges of the form when resizing the form We also defined the click handler scriptblock This sets the DialogResult property to OK When the form is closed, this is the value that will be returned from the call to ShowDialog().

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