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of treatment The peeling may be variable and usually begins after 2 days Kligman et al studied tretinoin 025% in a solution of 50% ethanol and 50% polyethylene glycol 400 in 50 women between 30 and 60 years of age with diagnoses of photoaging, rosacea, and acne The solution was applied to the face by the patients every other night for 2 weeks and later, on a nightly basis Patients showed clinical improvements as manifested by a smoother appearance of the epidermis, reduction of fine lines, and improvement of hyperpigmentation Histologic examination of the skin revealed increased thickness of the basal layer and fibroblasts in the papillary dermis, decreased numbers of melanosomes, diminished SC thickness, and better organized rete ridges Kligman and colleagues proposed that the effects of using low-strength tretinoin for 6 to 12 months may be achieved by higher strengths in 4 to 6 weeks34 Cuc et al conducted a study on 15 women between 23 and 40 years old with Fitzpatrick skin types I to IV to assess the clinical and histologic effects of a 1% tretinoin peel A pretreatment biopsy was done The chemical peel was performed with an interval of 2 to 3 days and patients had the peel on for 6 to 8 hours Fifteen days following the last application a second biopsy was performed, which showed increasing of the epidermal thickness and thinning of the SC35 These findings also correlated with clinically better looking skin The histologic and clinical evaluation of patients skin in this study indicated that to achieve the same effect of a tretinoin peel after 25 weeks one must use topical tretinoin for approximately 4 to 6 months In another study of 10 patients with Fitzpatrick skin types III to V and moderate to severe melasma, a 1% tretinoin peel was compared to a 70% glycolic acid peel The tretinoin peel was left on the treated area for 4 hours while the glycolic peel was placed for a maximum of 3 minutes Both peels were found to be equally effective at 3 months posttreatment, though less erythema and desquamation were associated with the tretinoin peel, which was therefore better tolerated by the patients36.



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PS (11) > "The point p is {0}" -f $p The point p is (6, 9)

So, in less than a hundred lines of PowerShell script, we ve added a new keyword that lets you define you own classes in PowerShell. Obviously, this isn t a full-featured type definition system; it doesn t have any form of inheritance, for example. But it does illustrate how you can use scriptblocks along with dynamic scoping to build new language features in PowerShell in a sophisticated way. Now let s change gears a bit to talk about types.

In this chapter, we described the basic properties of some elementary functions encountered in complex variables These included polynomials, the complex exponential, the trig functions, the logarithm, the hyperbolic functions, and functions with complex exponents





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You might have noticed that all of the examples we ve shown so far involve adding members to instances. But what about adding members to types Having to explicitly add members to every object we encounter would be pretty tedious, no matter how clever we were. We really need some way to extend types. Of course, PowerShell also let s you do this. In this section, we ll introduce the mechanisms that PowerShell provides which let you extend types. Type extension is performed in PowerShell through a set of XML configuration files. These files are usually loaded at startup time; however, they can be extended after the shell has started. In this section, we ll show you how you can take advantage of these features. Let s look at an example. Consider an array of numbers. It s fairly common to sum up a collection of numbers; unfortunately, there s no Sum() method on the Array class.

PS (1) > (1,2,3,4).sum() Method invocation failed because [System.Object[]] doesn't conta in a method named 'sum'. At line:1 char:14 + (1,2,3,4).sum( <<<< )

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as hydroquinone and azelaic acid Retinoids have the ability to increase the penetration of bleaching agents and chemical peels in addition to decreasing melanin production Tretinoin 001% in combination with 4-hydroxyanisole (Mequinol) has been shown to be effective in the treatment of solar lentigos78,79 Ortonne et al reported the effect of 4hydroxyanisole 2%/tretinoin 001% solution, and sunscreen in 406 patients with solar lentigines for up to 24 weeks; 325 patients (88%) had an almost complete fading of their facial lesions and 298 (81%) experienced the same in targeted forearm lesions80 In another study, Kang et al treated 90 patients exhibiting solar and actinic lentigines with adapalene gel (01% or 03%) and compared the results to its vehicle; 1 month following the treatment patients treated with adapalene gel showed significant lightening of their solar lentigines81 In addition, the use of tazarotene 01% cream once daily in 562 patients with facial photoaging for 24 weeks showed improvement of the lentigines and mottled hyperpigmentation by at least one point using a sevenpoint scale (0 represented complete response and 6 denoted worsening), when compared to its vehicle82 This treatment was followed by an additional 28 weeks of tazarotene 01% cream treatment, and continuing improvement was observed with no plateau effect83 Accordingly, it is important to inform patients that it may take a few months for topical retinoids to show depigmenting results It is also important to remember that patients with multiple solar lentigos are at an increased risk for skin cancer There is no evidence or reason to believe that successful treatment of these lesions leads to a lower melanoma risk Therefore, patients with significant numbers of solar lentigos, treated or untreated, should undergo routine skin cancer examinations

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