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(2006) Staying awake for dinner: hypothalamic integration of sleep, feeding, and circadian rhythms Progress in Brain Research, 153, 243 52 Savage, DB, Choi, CS, Samuel, VT et al (2006) Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2 Journal of Clinical Investigation, 116, 817 24 Sawchenko, PE and Swanson, LW (1982) Immunohistochemical identi cation of neurons in the paraventricular nucleus of the hypothalamus that project to the medulla or to the spinal-cord in the rat Journal of Comparative Neurology, 205, 260 72 Schmidt, PT, N slund, E, Gryb ck, P et al (2003) Peripheral administration of GLP-2 to humans has no effect on gastric emptying or satiety Regulatory Peptides, 116, 21 5 Schultz, W (2006) Behavioral theories and the neurophysiology of reward Annual Review of Psychology, 57, 87 115.



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Case study: planning a timber development Table 21.4 Capital cost estimate, normalized Item 1. Log handling 2. Saw mill 3. Drying 4. Dry mill and planer mill 5. Pressure treatment 6. Boiler 7. Turbo-alternator 8. Fresh water system 9. Offices 10. Workshop 11. Mobile equipment 12. Mill site 13. Port facilities Total civil and equipment 14. Construction overhead 15. Project engineering 16. Construction management 17. Start-up costs 18. Training Base estimate 19. Contingencies Total capital budget Base cost 17 15 8 7 3 11 6 4 1 2 4 3 5 86 3 6 1 1 3 100 10 110





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Schutt, C, Bernheiden, M, Grunwald, U et al (1999) Implications for a general role of LPS-binding proteins (CD14, LBP) in combating bacterial infections Journal of Endotoxin Research, 5, 75 80 Schwartz, MW, Seeley, RJ, Camp eld, LA et al (1996) Identi cation of targets of leptin action in rat hypothalamus Journal of Clinical Investigation, 98, 1101 6 Schwartz, MW, Woods, SC, Seeley, RJ et al (2003) Is the energy homeostasis system inherently biased toward weight gain Diabetes, 52, 232 8 Sclafani, A (2001) Psychobiology of food preferences International Journal of Obesity, 25, S13 5 Scott, TR and Giza, BK (2000) Issues of gustatory neural coding: Where they stand today Physiology & Behavior, 69, 65 76 Simerly, RB (2004) Anatomical substrates of hypothalamic integration, in The Rat Nervous System (ed G Paxinos), Elsevier, Amsterdam, pp.

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A key component of hierarchical protein structure classi cation involves recognition of secondary structure composition and patterns of arrangement within protein structure les in the PDB. Protein folds are quite robust to changes in primary structure with the result that sequence alignments can miss similarities in proteins, which may nonetheless adopt similar folds and hence possibly have similar function. Specialist structural databases allow us to classify proteins into three-dimensional classes based partly on their composition and arrangement of secondary structure elements. The best known of these are CATH and SCOP (Table 9.3). CATH classi es proteins based on four levels of structural hierarchy (Figure 9.22). Class is automatically assigned as mainly -helix, mainly -sheet, mixture of -helix/ -sheet and proteins with especially low composition of -helix/ sheet. Architecture is manually assigned based on wellknown secondary structure arrangements such as -barrels

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a. For teleradiology applications, software for image acquisition, patient data input, and data communication. b. For telemicroscopy applications, software control of for (i) automatic focusing, and (ii) automatic x-y stage motion; color lter switching; and frame grabbing. These tools are needed for converting slides to digital images. c. A database for managing images and textual data. d. A standard communication protocol for LAN and WAN. A light microscope with software control of: automatic focusing, x-y stepping motor controlled stage, RGB color lters, and a CCD camera Standard communication hardware for LAN and WAN Communication networks connection (e.g., T1 or DSL). The WS at the expert site should be able to display1K x 1K gray level and color images with standard graphical user interface. It needs a database to manage local data. The WS should be able to control microscopic stage motion as well as automatic focusing. Telemicroscopy Applications

As mentioned, a variety of plastics are used in lesser quantities than the major packaging plastics discussed above. These materials are, in general, signi cantly more expensive but have speci c properties that make them important for particular types of applications.

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