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To create a perspective view in 3D Orbit, right-click and choose Perspective. To return to parallel view, choose Parallel. For more information on perspective views, see the section Displaying Parallel and Perspective Projections earlier in this chapter.

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systematic process in place to accurately evaluate a change using speci c tests. Moreover, it aims to measure the effects on quality safety and ef cacy before a change is implanted. Change control and its evaluation through proper documentation should include [14]: (a) Description and purpose of change (b) Inputs from research and development (R&D) department (c) Evaluation steps for impact assessment, such as evaluation of stability, validation requirements, and in vivo bioequivalence requirement (d) Need and extent of regulatory documentation and approval (e) Implementation schedule (f) Clear de nition of personnel authorized for change approval (g) Monitoring protocol for change implementation and periodic review of impact Following the informal proposal of a change, it should be reviewed by the responsible initiator, who will then generate a formal proposal [15]. The proposal should describe accurately what the change is concerned with, how to validate the change, and the time frame within which the change should be implemented. The nal proposal should be reviewed and assessed by all functional groups involved. Once the change is approved, it can be implemented and the change cycle is completed. Figure 2 describes responsibilities of different departments of a pharmaceutical company,





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1-Anilino-8-naphthalene sulphonate (ANS)

1

H (henries),

As seen above, the harmonic-generating element in an active doubler is mainly the controlled current source; this is a resistive nonlinearity that has an in nite bandwidth, in

where L is the half-cell length. For typical proton ring designs, the product 8L tends to be about 1 meter. Since the phase advance per cell, p, also is apt to be selected from a narrow range, the dispersion is about the same regardless of the peak energy of the synchrotron. It will be interesting to see if this scaling perseveres in the future.

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vinyl), N (i.e., iminyl), or O (i.e., carbonyl). If the dicoordinated carbon atom is not involved in formal p bonding, then it is considered to be a carbene center and its p acceptor ability ranges from moderate to high, depending upon whether its two substituents are themselves good p donors (N or O) or not (alkyl or H). Similar considerations apply to a monocoordinated carbon atom which functions as a ligand to a transition metal. The carbon atom may have two formal p bonds to its attached atom, as in acetylides, cyanide anion, or carbon monoxide. Such compounds coordinate in a linear fashion and can accept p electrons equally in the two orthogonal planes. The p acceptor ability ranges from poor to moderate. The electrically neutral carbonyl group may formally donate electrons to one metal and accept electrons from another and therefore bridge the two. If the two metals are similar, the CO molecule acting in this fashion is functionally equivalent to a ketone carbonyl group. Acetylides and cyanide cannot function in the same way because neither the carbon atom nor the nitrogen atom are electronegative enough to support the extra nonbonded electron pair and the negative charge. Substitution by an alkyl group on N or a second alkyl or hydrogen on C permits the carbon atoms of these groups to coordinate to two metals as well. The groups are vinylidene and isonitrile, respectively. CHELATING LIGANDS Chelating ligands such as en (ethylenediamine), acac (acetylacetonate), and alkyl separated phoshines can be regarded as the equivalent number of L: and X: groups. Thus en L2 and acac LX. The length of the chelating bridge may impose a geometry restriction, however, forcing an interligand bond angle to be less than 90 , for instance. ORGANIC

template element defines a template, while the apply-template and call -template elements declare where in the stylesheet a template should be invoked.

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of using PACS and image distribution as a key technology in providing better quality and more cost-effective healthcare delivery at the enterprise level. As a result many large-scale enterprise-level PACS/image distribution pilot studies are under way, concerning full design, and implementation. Some of the larger enterprise PACS currently being designed, developed, and implemented around the world are as follows:

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