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FIGURE 22-32 Injection sites on hands are approximately 15 cm apart further injections The use of other serotypes (F or B) may benefit those who have developed antibody resistance There are two types of therapy resistance to BTX, primary and secondary A patient who does not respond to the first injection of BTX-A is referred to as a primary nonresponder, but reasons for nonresponse can include inappropriate site of injection, poor technique, and/or insufficient dose109,110 Immunogenicity should be suspected in a patient who no longer responds to BTX-A ( secondary nonresponder ) following a successful course of earlier injections Antibody formation could be targeted against the neurotoxin component of BTX or against its nontoxic protein component The recommended approach is to inject 20 U BTX into the hypothenar or forehead muscles If the patient responds to BTX, then transient weakness will develop in the muscle 1 to 2 weeks after injection An alternative is to take blood for an antibody assay that is rarely used In secondary nonresponders, the problem can be further overcome by using a different BTX serotype, for example, BTX-B if resistance develops to BTX-A Risk factors for the development of antibodies include higher doses, shorter intervals between injections, booster doses, and young age Recommendations to help prevent development of antibodies include the following: (1) use of the smallest possible dose to achieve relief, (2) an interval between injections of at least 1 month (the preferred interval is 3 months), and (3) touch-up injection avoidance Many researchers have postulated that the risk of antibody formation is due in part to the quantity of protein or the protein load of the toxin, the type of protein present in the toxin, and to other factors listed in Table 22-6 Manufacturers of BTX have attempted to minimize each of these factors in order to create a less immunogenic product For example, the original Botox that was used until December 1997 contained a higher level of protein than the Botox currently in use; therefore, it.

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