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ring23 Cumulative UV exposure and the additive effect of molecular remodeling results in visible photoaging, characterized by wrinkles and decreased skin tone Histologically, photoaged skin reveals disorganized dermal collagen fibrils and increased elastin In addition to their ability to induce cytokines and chemokines, TLRs have been implicated in the induction of MMPs Several preliminary studies have shown that microbial agents are capable of inducing MMP expression through a TLR-dependent pathway For example, in Lyme disease the causative agent Borrelia burgdorferi is capable of inducing MMP-9 through a TLR2-dependent mechanism51 Moreover, mycobacterial cell wall components are also thought to increase MMP-9 through TLR252 More recently, CpG oligodeoxynucleotide, the ligand for TLR9, exhibited the capacity to induce MMP-9 expression in macrophages via a TLR9/NF- B-dependent signaling pathway53 Not all TLR pathways behave equally with regard to MMP regulation Imiquimod, a TLR7 and 8 ligand, downregulates production of MMP-9 while simultaneously upregulating TIMP expression54 Clinical evidence to support the role of 5% imiquimod cream in the reversal of photoaging and actinic damage was recently described by Kligman and colleagues The daily application of imiquimod cream for 5 days each week for 4 weeks resulted in a decrease in wrinkles, dyspigmentation, and hyperkeratotic pores Histologically, reversal of epidermal atypia and atrophy were observed in posttreatment biopsies55 In this regard, imiquimod appears to have potential as a novel therapy for reversal of photoaging as well as the prevention of cutaneous neoplasms The exact role imiquimod exerts in regulating the expression of MMP in vivo has not been determined and further studies are warranted in this area

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Now $LASTEXITCODE contains the value the script exited with, which is 25, and $ is set to false. So far, we ve looked at how to capture errors and how to detect when they occurred. Next we ll look at some of the methods PowerShell provides to control what actually happens when an error is generated. 9.1.4 $ErrorActionPreference and the -ErrorAction parameter Earlier, we talked about the differences between terminating and non-terminating errors. Sometimes you want to be able to turn non-terminating errors into terminating ones because the operation you re performing is too critical to tolerate non-terminating errors. For example, imagine you re setting up a website for a user. You want to reuse a directory that had been previously used for someone else. First you want to remove all the old files and then install the new user s files. Obviously, you can t start installing the new files until all the old ones are deleted. In this situation, the failure to delete a file, which is normally a non-terminating error, must now be treated as a terminating error. The next step in the process can t begin until the current step is 100 percent complete.

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The way to control whether errors are terminating or non-terminating is by setting the error action preference. This is a mechanism that allows you to control the behavior of the system when an error occurs. There are three possible settings for this preference: continue, silentlycontinue, and stop. These preferences are described in table 9.2.

Table 9.2 The supported values for ErrorActionPreference Identifier continue Description This is the default preference setting. The error object is written to the output pipe and added to $error, and $ is set to false. Execution then continues at the next script line. When this action preference is set, the error message is not written to the output pipe before continuing execution. Note that it is still added to $error and $ is still set to false. Again, execution continues at the next line. This error action preference changes an error from a nonterminating error to a terminating error. The error object is thrown as an exception instead of being written to the output pipe. $error and $ are still updated. Execution does not continue.

There are two ways to set the error action preference: by setting the variable $ErrorActionPreference as in

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Facial erythema and flushing are seen in many dermatologic and systemic disorders A clinical history and physical examination are very important aspects of the patient evaluation The Baumann Skin Type Indicator (BSTI) can help determine patients at risk for developing rosacea by asking them historical questions about facial flushing (see 9) Laboratory tests may be needed to rule out systemic diseases, such as collagen vascular disorders, if these are suspected Table 16-3 lists the differential diagnosis of rosacea26

or by using the -erroraction (or -ea) parameter that is available on all cmdlets. Let s see some examples of these preferences in action. Here s a simple one. First we ll run a command that has some non-terminating errors. We ll use the Get-Item cmdlet to get two items that exist and two items that don t exist.

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