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role in allergic inflammation mostly occurs through the H1-receptor18,19 Through this receptor, histamine plays a proinflammatory role by inducing the release of cytokines and lysosomal enzymes from macrophages and the expression of cell adhesion molecules18,19 Additionally, it influences the activity of basophils, eosinophils, and fibroblasts, causing smooth muscle contraction20 Although most of the effects of histamine in inflammatory allergic disease occur through the H1-receptor, cutaneous itch may occur through both the H1- and H3-receptors21



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In this case, the output is the ToString() of the exception. However, $_ is not an exception; it s an error record, so the trap handler has full access to all of the information in the error handler. Let s verify the type of this object.

PS (6) > trap { "Got it: " + $_.gettype(); continue Got it: System.Management.Automation.ErrorRecord

( s i )

} 1/$zero;

In the trap block in this example, we re displaying the type of the value in $_. Let s look at a somewhat more complex example. We said earlier that control transfers to the next statement after the one that caused the exception. That s not quite true. It transfers to the next statement in the same scope as the trap statement. In this example, we ll use scriptblocks to create the two scopes.





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Oxygen-derived free radicals may be released extracellularly from leukocytes after exposure to pathogens, chemokines, and immune complexes, or following a phagocytic challenge22 The physiologic function of these reactive oxygen intermediates is to destroy phagocytized microorganisms Their production depends on the activation of the nicoti-

( s + i )

PS (7) > &{ >> trap {"TRAP"}

>> &{

>> >> >> >> "three" "four" } "OUTERBLOCK"

The integral is already divided by 2 i, so by the residue theorem f (t ) = res = ei t e i t sin t = 2i 2i

Look at the output that was produced. You can see the first couple of numbers printed and then the exception, but look where execution resumed at the first statement outside the block. This pattern allows you to skip entire sections of code instead of a single line. It essentially mimics the try/catch pattern found in other languages such as C#. Having mastered catching exceptions, let s look at how to throw our own.

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namide adenine dinucleotide phosphate (NADPH) oxidative system, which is a membrane-bound enzyme complex This system can be found in the plasmatic membrane as well as in the membrane of phagosomes inside the cells Superoxide anion (O2 ), hydrogen peroxide (H2O2), and hydroxyl radical (OH) are the major species produced within the cell; these metabolites can combine with nitric oxide (NO) to form other reactive nitrogen intermediates23 (see 34) Extracellular release of low levels of these potent mediators can increase the expression of chemokines, cytokines, and endothelial leukocyte adhesion molecules, amplifying the cascade that elicits the inflammatory response At higher levels, the release of these mediators can induce endothelial cell damage, which results in increased vascular permeability, neutrophil degranulation, and inactivation of antiproteases, such as 1-antitrypsin, leading to increased destruction of the extracellular matrix24 Serum, tissue fluids, and host cells all possess antioxidant mechanisms that pro-

The throw statement To complete the error-handing story, we need a way to generate terminating errors or exceptions. This is accomplished by using the throw statement.

Summary

In the original design, throw was supposed to be a cmdlet rather than a keyword in the language. This was less successful than we would have liked. Having a cmdlet throw the exception meant that the thrown exception was subject to the cmdlet s error action policy, and the whole point of throw was to bypass this policy and always generate an exception. It wasn t so much a case of the tail wagging the dog as it was staple-gunning the poor beast to the floor. And so, learning from our mistakes, we made it into a keyword.

The syntax of the throw statement is shown in figure 9.2. The simplest example is to throw nothing:

In this chapter, we explored more complex integrals and introduced the Laplace transform, a tool which can be used to solve differential equations algebraically The inverse Laplace transform is de ned using a contour integral called the Bromvich inversion integral

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