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Figure 8.2 This is the result of a numerical simulation of the two dimensional Brownian motion of a single particle (e.g., a grain of pollen). The large plot shows the actual trajectory of the particle. The position the particle had when we started to follow its path was chosen as the origin of coordinates (i.e., x = 0, y = 0). On the inset, the x-coordinate of the particle is plotted against the time. The units are arbitrary and the diffusion constant was taken as 1.



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The trimers are very active in polymerization, ranging from 102 - to 105 -fold more active than the tetramers Each aluminum atom (and its associated alkoxide groups) in the reaction system will not be active in polymerization unless the equilibrium exchange between trimer and tetramer is fast The equilibrium is rapid at higher temperatures, at lower initiator concentrations, and in more polar solvents, and one observes the theoretical maximum stoichiometry between propagating chains and metal atoms Under other conditions, less than the maximum stoichiometry is observed Aggregation phenomenon are also observed for the propagating chains, with an equilibrium between aggregated and unaggregated chains This is the equivalent of a reversible deactivation between dormant and active propagating chains that preserves the livingness of the polymerization In other living systems the reversible deactivation involves a different phenomenon.





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on suspensions of fine inorganic particles, Brown soon concluded that it was not a manifestation of life.

Cationic living polymerization of C C monomers involves an equilibrium between covalent (dormant) and ionic (active) species ATRP involves reversible formation of radicals from the reaction of an alkyl halide with a metal The presence of aggregated species results in fractional-order dependencies of initiation and propagation rates on initiator and propagating species (Sec 5-3d-5) Polymerization of b-propiolactone (also called 2-oxetanone) shows some interesting features due to the high strain in the 4-membered ring [Duda, 1992; Jerome and Teyssie, 1989] Polymerization with the less nucleophilic initiators such as tertiary amines, metal carboxylates, and phosphines proceeds with ring opening at the alkyl oxygen bond instead of the acyl oxygen bond Initiation by stronger nucleophiles occurs by acyl oxygen as well as alkyl oxygen cleavage to give a mixture of carboxyl and alkoxide propagating centers.

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The first satisfactory explanation of the riddle of Brownian motion was given by Albert Einstein in 1905, his famous anno mirabilis [181]. What follows is an account of his theory slightly adapted to fit our discussion here. Einstein started his analysis from the hypothesis that the swarming motion of a grain of pollen was caused by the frequent pushes it received from collisions with the thermally agitated molecules of the liquid. Now if the viscosity of the liquid is high enough, the movement imparted by one such impact will quickly dampen, so that the motion caused by further impacts will be completely independent of the preceding one (i.e., there is no memory of the previous motion). Assuming that this was the case, Einstein introduced a time interval T much shorter than observable time intervals, yet large enough for the viscous friction to do its job of making the motions in two successive time intervals T be independent events. Einstein examined the motion in one dimension, which we can call the x-axis. For N suspended particles in a viscous liquid, the x-coordinate of each particle will increase by a certain amount in a time interval T. As we cannot keep track of the movement of every molecule in the liquid, all we can hope for is to describe this amount by a statistical probability distribution. Let dN" be the number of particles whose increase in x is between D. and D. + dD.. Then the probability distribution </>( D.) of increase in x is independent of time and defined by

However, the carboxylate centers are unable to propagate by cleavage of acyl oxygen bonds while alkoxide propagating centers cleave both alkyl oxygen and acyl oxygen bonds Alkoxide propagating centers convert to carboxylates with time, and carboxylate centers constitute more than 95% of all propagating centers after only several propagations Polymerization of b-propiolactone in a highly polar solvent (DMF) in the presence of a crown ether shows the unexpected feature that ion-pair reactivity decreases more slowly with decreasing temperature compared to free-ion reactivity [Penczek et al, 2000a,b; Slomkowski, 1986] Solvation of free ions becomes so extensive at 20 C that they are less reactive than ion pairs 7-5b Cationic Polymerization.

Cationic polymerization of lactones is achieved with the range of initiators used for cyclic ethers (Sec. 7-2b) [Hofman et al., 1987a,b; Kricheldorf and Sumbel, 1988a,b; Kricheldorf et al., 1986, 1987a,b; Kubisa, 1996; Penczek and Slomkowski, 1989a,b]. Initiation was formerly thought to involve attack of a positive species on the endocyclic oxygen to form an

dN" = N </>(D.) dD.,

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