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capture the information in a gene (Johnson et al., 2001). Among the advantages of this approach is that it will be possible to resolve the contribution of a speci c gene to a trait or disease and not be left with the rather common conclusion that the observed association may be the result of a functional mutation yet to be identi ed that is in linkage disequilibrium with the polymorphism examined. Greatly aiding this process is the fact that although there are nearly enumerable haplotype possibilities at any given gene, the realized array of haplotype variation is a much reduced subset (Stephens et al., 2001). As with single polymorphisms, these haplotypes show marked variation in frequency among populations. There are some haplotypes that seem to be distributed ubiquitously across populations, but there are others that are characteristic of a single population (Stephens et al., 2001). Imbedded in these haplotype frequencies is a great amount of information regarding the evolution of these genes, potential selective constraints, indicators of population structure, and information that will permit the identi cation of disease and drug-response genes.

consumers invited to participate through phone calls and email. We believe that more companies will adopt the Hallmark model of close consumer involvement with product design and service feedback in the future, so in February 2002, we conducted an interview with the initiator of the Idea Exchange, Tom Brailsford. Since the report that informed our initial description of the consumer-asconsultants project, Hallmark has started two more online communities: one for grandparents and one for Hispanics. As with the original community, made up of mothers with young children, the company plans to limit the populations to about 200 members at a time. Additional communities specifically, their composition are under discussion within the company. Brailsford says that one way consumer communities save his company money is by enabling faster research. There s a financial value associated with time too.

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// Test whether to fail an alloc in the current state bool AllocShouldFail( TAllocState *aState )

If there hadn t been success stories from applying knowledge networking techniques, we would not have been persuaded to write this book. In fact, there is enough buzz around the idea to excite business leaders at all levels. Some of the better known examples of large companies that have begun utilizing their human intellectual capital are referred to on the AskMe site,19 one of the Web s most creative knowledge-sharing oases. Here are some of these companies, the description of their knowledge networking activities, and the bottom-line results they reported from those activities:

p0=1/temp; pq=pow(tC*rho,C)*p0/(factorial(tC)*(1-rho)); Nq=pq*rho/(1-rho); wq=Nq/lambda; Ts=wq+1/mu; Ns=lambda*Ts; dc.SelectObject(fontTimes); dc.SetBkColor(RGB(255,255,255)); dc.SetTextColor(RGB(100,100,100)); s.Format( Arrival Rate, lambda: %lf ,lambda); dc.TextOut(450,360,s); s.Format( Mean service time, mu: %lf ,mu); dc.TextOut(450,385,s); s.Format( Counter utilization rate, rho: %lf ,rho); dc.TextOut(450,410,s); s.Format( Prob. of having no customers, p0: %lf ,p0); dc.TextOut(450,435,s); s.Format( Mean sojourn time, Ts: %lf ,Ts); dc.TextOut(450,460,s); s.Format( Mean number of customers in the system, Ns: %lf ,Ns); dc.TextOut(450,485,s); s.Format( Prob. of queueing (Erlang-C), pq: %lf ,pq); dc.TextOut(450,510,s); s.Format( Expected number of customers in queue, Nq: %lf ,Nq); dc.TextOut(450,535,s); s.Format( Mean waiting time in queue, wq: %lf ,wq); dc.TextOut(450,560,s); }

1. Kim Willsher, Bidding Breaks Sound Barrier as Planespotters Swoop for Concorde Memorabilia (London: The Sunday Telegraph, November 16, 2003), p. 18. 2. Oliver Poole, Mixed-Up Mickey Gets a Makeover at 75 (London: The Daily Telegraph, November 19, 2003), p. 15.

where a is the voltage gain of the op amp, Rf /(Rs + Rin ). Here vn multiplied by the gain from the noninverting input (i.e., 1 + a) equals en multiplied by a, the gain from the inverting input. Adding these three equivalent mean-square input voltages and dividing by the voltage equivalent to the available power from the source resistor, we obtain the

group, there are few organizational concerns The main questions about membership are how many should there be and who should be invited As the community grows and diversifies attending to wider ranges of knowledge and serving different groups and needs organizational issues arise These have to do with leadership, responsibility, and access rights How will the discussion space be partitioned and controlled Who will have access to the tools for managing the interface and the database of conversations Will policies for participation be the same across all communities, or will there be different ground rules in different forums Each group must consider, for example, how it will determine membership.

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