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of organism-environment interactions can make use of a broad array of response systems, including electrodermal reactivity, pupillary responses, electromyographic changes, cardiovascular changes, and effects on hormonal and endocrine regulation Several issues confront the neuropsychological researcher who is considering adopting a psychophysiological approach to investigation One important issue is whether the research question demands an evaluation of time-locked (phasic) changes in physiological reactivity or an investigation of some generalized (tonic) level of activity in a physiological channel An example of the former approach would involve questions about the degree to which remembered versus forgotten information was associated with time-locked physiological reactivity at the time of encoding (Diamond et al, 1996; Verfaellie, Bauer, & Bowers, 1991) An example of the latter type of question would be an investigation of the effect of acquired brain damage on nonspeci c cardiac or hormonal activity (eg.



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, Emsley, Roberts, Aalbers, Taljaard, & Kotze, 1994) A second issue concerns the selection of speci c response systems or variables for study Measurement selection may be governed by a number of factors, including invasiveness, ease of use (eg, computational intensity), and sensitivity and speci city to the psychological constructs under study For example, the measurement of electrodermal activity has been popular in a wide range of experiments because it is easy and inexpensive to collect and simple to quantify and because electrodermal activity is sensitive to a wide range of manipulations affecting psychological effort, arousal, surprise, and signi cance detection (Dawson, Schell, & Filion, 2000) However, within this advantage is a potential limitation: Unless the experimental task is appropriately controlled (for example, controlling for task dif culty across levels of arousal), it is sometimes dif cult to precisely interpret the source of increased electrodermal activity.

For example, just because some studies suggest that larger electrodermal responses occur in situations in which novel, signi cant stimuli are detected (Bernstein, Taylor, & Weinstein, 1975) does not mean that electrodermal responding can be simply inferentially applied as a signi cance detector An excellent review of inferential concepts in psychophysiological research is given by Cacioppo et al (2000) A third issue concerns the selection of an approach to instrumentation and data analysis There are numerous ways to collect psychophysiological data, and the fact is that many neuropsychologists and cognitive neuroscientists might want to apply these methods without the typical didactic or empirical training that would characterize the mainstream psychophysiological researcher Consensus statements exist regarding appropriate methods for instrumentation, recording,.

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