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In other micronutrient de ciency states, there is usually a marked decline in tissue levels of the nutrient before other manifestations of de ciency become apparent In the case of zinc, the reduced food intake and growth are regarded as a homeostatic response to conserve the tissue zinc for its essential metabolic functions In studies carried out in Colorado, USA, it has been shown that mild zinc de ciency may be a contributory factor in the low growth rate of some children and that zinc supplements may have a signi cant impact upon nal height in children who have a low height for age Healthy children who had low height for age were selected for a double-blind, placebo-controlled trial of the effect of zinc supplements upon their growth Small zinc supplements (5 mg/day) increased height signi cantly in these growth retarded children as compared with children receiving a placebo.



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Parallel studies of zinc supplements in children who were randomly selected (not selected on the basis of height) did not show any impact of zinc supplements (reviewed by King and Keen 1999) Other manifestations of experimental zinc de ciency include reduced immune function, slow healing, hypogonadism and delayed sexual maturation, skin lesions, hair loss and other lesions in epithelial tissues Zinc de ciency in pregnant animals leads to increased numbers of fetal abnormalities including cleft lip and palate and spina bi da Severe de ciency of zinc in humans has been experimentally induced, occurs when zinc-free infusions have been used in total parenteral nutrition and also occurs in a rare inherited condition called acrodermatitis enteropathica in which there is impaired absorption of zinc This latter condition can be controlled by oral zinc supplements.





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In the 1960s and 1970s many cases of zinc responsive growth failure and hypogonadism were identi ed in parts of Egypt and rural Iran Diets in these regions consisted largely of unleavened wholegrain bread and it is thought that the high phytic acid content of this bread was an important precipitating factor because it impairs zinc absorption Phytic acid is destroyed during the fermentation process when leavened bread is made Zinc was mentioned several times in the earlier discussion in 2 on the micronutrient adequacy of different age groups within the UK Recorded average intakes of zinc are only just above the RNI for young and middle-aged men and women and slightly below it in older adults In the UK, the RNI for zinc is not increased during pregnancy although in the USA it is increased by around 40%.

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The other eigenvalues are 0.3 with eigenvector [1 7 8]T and 0.4 with T eigenvector [1 0 1] . These are not needed here. 22. The growth rate is 3. A corresponding eigenvector is [40 10 1]T, but is not needed. Neither are the other two eigenvalues 0 with eigenvector [0 0 1]T and 3 with eigenvector [40 10 1]T. 24. Team Project. (a) This follows by comparing the coefficient of n 1 in the expansion of D( ) with that obtained from the product representation. (b) Axj 0), (A kI)xj kxj ( j k)xj jxj (xj jxj (c) The first statement follows from Ax x, (kA)x k(Ax) k( x) (k )x,

For lactating women the RNI for zinc is more than doubled and as food intake increases only by a quarter this would suggest that average intakes are substantially below the RNI Average zinc intakes of pre-school children in the UK are below the RNI and substantial numbers of older children have intakes that are below the LRNI In elderly people, especially elderly men there is evidence of.

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