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By the same token, if the FDA sends the company back to check what looks like a spate of side effects, and it turns out that it was only one patient with a history of heart troubles unrelated to the drug, then that is an extra level of assurance for the company as well as the FDA, which the company can certainly parlay to good advantage in its marketing ( This drug has not been found to cause.. ) What the agency does is call from you an enormous level of analysis they call from you excellence, said Boyd Clarke, the former Merck executive who now runs the Philadelphia-area biotech Neose The story of Eli Lilly s Axid, a histamine blocker for ulcers and heartburn, shows not only how FDA intervention can improve a clinical trial, but also how no one else but the FDA could do it.



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Lilly was ready to start its trials of Axid in 1985, recalled Leigh Thompson, when two of the FDA s top reviewers suggested a radical change in protocol Instead of running a standard double-blind study using the drug and a placebo for eight weeks straight, the reviewers proposed limiting the initial test to four weeks, then randomly reshuffling the patients for the remaining four weeks so that some of the people originally on the drug would now have the placebo, and vice versa That way, Thompson said, we were able to track how many [patients] had ulcers go away on the drug and come back on the placebo The drug acted faster than we expected and wore off faster than we realized We got much better data, and it didn t cost us more.





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The FDA reviewers had based their suggestion on something only they could have known: the trial results from other, similar drugs Similarly, the FDA once requested that Gilla Kaplan alter a trial in which she was trying to see if injecting recombinant molecules would stimulate a better immune response from leprosy patients (This was separate from her work on thalidomide) While Kaplan had wanted to test 50.

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Well, now, welcome back to the land of the living. For a little while, at least, you re not a robot. You re not thinking like a lemming. As the movie trailer guy says, In a world of robots and lemmings, you don t have to follow anyone over a cliff. And hey, he s right; you re free to create the life you want. If I were you, I d mark this chapter and come back to it often maybe every time you start to think about your investments. Instead of aimlessly searching for some priest, or guru, or expert to do your thinking for you, here s a simple step-by-step process. It s basically the process great investors like Steven Schwarzman of The Blackstone Group use. Schwarzman, by the way, was the highest paid executive in the United States last year at around $700 million. Just start from scratch and build your own strategy, undistorted by the pull of the herd. You re about to become your own leader. You re about to start thinking like a billionaire. I can tell you from experience, the big money will follow. Here then, are a couple of simple steps to devising your own strategy instead of following the lead lemmings. At the same time, I ll also give you some in-depth directions on how to get them right. Ready Here we go. First, forecast future events using vision instead of extrapolation. Consider tactical moves and adjust your forecast based on your estimate of their success. How con dent are you in your forecast Make a realistic assessment of the chances that you re wrong. WARNING:

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