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They designed an azobenzene-containing multibilayer vesicle with an intercalated inorganic magnetic compound (Prussian blue) and showed that the magnetic property of such a nanomaterial could be reversibly altered as a result of a geometrically con ned structural change induced by the photoisomerization of azobenzene In smallmolecule photosensitive surfactants, azobenzene moiety is generally part of the hydrophobic tail or positioned close to the polar (ionic or nonionic) head In either case, the different polarity of azobenzene in the elongated trans and bent cis forms can cause changes in the hydrophilic hydrophobic balance that affects the selfassociation of surfactant molecules The important molecular shape change of azobenzene accompanying the trans cis photoisomerization can also contribute to the destabilization of micelles self-assembled by small-molecule surfactants The incorporation of azobenzene into amphiphilic block copolymers (BCPs) to make light-controllable polymeric micelles has not been reported until 2004 (Wang et al, 2004).



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interface) between the application and the network, since the socket is the programming interface with which networked applications are built in the Internet The application developer has control of everything on the application-layer side of the socket but has little control of the transport-layer side of the socket The only control that the application developer has on the transport-layer side is (i) the choice of transport protocol and (ii) perhaps the ability to fix a few transport-layer parameters such as maximum buffer and maximum segment sizes Once the application developer chooses a transport protocol (if a choice is available), the application is built using the transport layer the services offered by that protocol We will explore sockets in some detail in Sections 26 and 27





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The interest of such azobenzene-containing BCP micelles resides in the context of developing polymer nanocarriers for controlled delivery applications, which has been the subject of intensive research effort worldwide because of the high stakes (Gaucher et al, 2005; Haag, 2004; Discher and Eisenberg, 2002; Kwon and Kataoka, 1995) BCP micelles have some important advantages over their small-molecule counterparts with regard of nanocarriers These include the following: (1) BCP micelles can be more stable in solution and thus afford more stable encapsulation of guest molecules, owing to a much lower cmc and the macromolecular nature (eg.

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The Fault Tree Analysis (FTA) is one of the tools described in SAE document ARP 4761 [1]. This analysis technique uses probability to assess whether a particular system con guration or architecture will meet the mandated requirements. For example, assume that the total loss of aircraft electrical power onboard an aircraft has catastrophic failure consequences as identi ed by the Functional Hazard Analysis see Figure 11.2 and Table 11.1 above. Then the safety objective quantitative requirement established by FAR/JAR25.1309 and as ampli ed in ARP 4754 will be such that this event cannot occur with a probability of greater than 1 10 9 per ight hour (or once per 1000 million ight hours). The ability of a system design to meet these requirements is established by a FTA which uses the following probability techniques.

, a high Tg or the crystallization of the hydrophobic block can render the core of micelle more compact and their dissolution slower) and (2) their sizes can easily be adjusted, by changing the lengths of the blocks, to be in the 20 100 nm range to allow their preferential accumulation in porous cancer tissues through the enhanced permeation and retention mechanism (Haag, 2004) To understand the interest of azobenzene BCP micelles, the question about the utility of light-controllable polymer micelles needs to be answered Using BCP micelles as a nanocarrier of drugs, an effective target-speci c delivery of drugs should consist in three steps The rst step is a stable encapsulation of the drug, meaning that after administration in the body, the BCP micelle protects the drug and prevents it from leaking out quickly..

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