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Bray established the key role of type-1 IFN in the resistance of mice to the Ebola virus infection, showing that signi cant compromise of the interferon response gave rise to disease progress resembling that in primates.11 In line with these latter observations, Harcourt et al.12 found that induction of the major histocompatibility complex class I family of genes, OAS, interleukin-6 (IL-6), PKR, interferon (IFN) regulatory factor-1, and intercellular adhesion molecule-1 (ICAM-1) by dsRNA in human umbilical vein endothelial cells was suppressed by infection with the lovirus Ebola-Zaire. Likewise, Ebola and Marburg viruses each could infect dendritic cell cultures and support exponential viral replication without releasing. Adenovirus (AV), Epstein-Barr virus (EBV), and human immunode ciency virus type 1 (HIV-1) all encode small RNA ranscripts that bind to the active site for dsRNA binding.20,45,53,54 In uenza virus NS1 protein binds directly to PKR but has also. 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