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stimuli was associated with decreases in left temporo-insular cortical blood ow (Gordon et al., 2000). Further studies are needed to elucidate brain activity patterns in patients with eating disorders using the same provocation paradigms. Speci c ligands for serotonin and dopamine sites can be utilised to clarify the involvement of these neurotransmitter systems in eating disorders. Data of PET with altanserin, a serotonergic ligand that binds to 5-HT2a receptors, in 9 women who had recovered from bulimia nervosa versus 12 normal controls, have shown reduced 5-HT2a binding in the medial orbital frontal cortex, an area involved in regulating emotional and impulse control (Kaye et al., 2001). A study in 16 women recovered from anorexia nervosa versus 23 controls demonstrated signi cantly reduced altanserin binding in mesial temporal and cingulate cortical regions (Frank et al., 2002). These studies suggest that altered 5-HT neuronal system activity may persist after recovery from BN or AN.

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Because all the model elements shown in Fig. 3.5.2 are available in the CAD program SPICE, the simulation results given below can be obtained by using SPICE [13]. For an asymmetric coupled two-line system (also called a 4-port), the SPICE model, model parameters, and its step response are shown in Figs. 3.5.3a e. The step

5 perplasia and 2 patients were identi ed with cancer.31 Additionally, there have been case reports of patients treated for hyperplasia with an LNG IUD progressing to endometrial carcinoma.35 It appears that LNG-containing IUDs are very successful when treating hyperplasia without atypia, and generally have a good response among patients with atypia. Systemic effects of progestins should be limited during the duration of IUD use. Formal randomized trials are needed to determine if they have a better response rate than systemic progestins. However, careful surveillance in patients initially treated for atypical hyperplasia is necessary. Surveillance can include either transvaginal ultrasound or endometrial biopsy. It appears that patients with endometrial stripes that are thinking or are less than 5 to 6 mm while being treated for atypical hyperplasia will have resolution, while those who have thicker stripes ( 10 mm) or whose endometrial stripe thickness increases during treatment are at higher risk of persistence or progression.28, 33, 35 For evaluation of histologic regression after placement of an LNG IUD, of ce endometrial pipelle can be performed with the IUD in situ. Endometrial sampling should be done every 3 months until regression and then every 6 months after that, alternating with TVUS.

where the norms on the right-hand side are the vector Holder norms and the induced matrix norms on the left are called subordinate to the corresponding Holder norms. The 2-norm de ned in this way is also called the spectral norm of A. It has the properties: kdiagi li k2 max jli j

RMS error (deg)

Uplink [MHz] 2500-2570 1920-1980 1850-1910 1710-1755 1710-1785 1750-1785 880-915 824-849 830-840

1997, pp 1431/1432) Although this laboratory study might be a good example of a high stake study, it also raises serious ethical concerns To what extent is it ethically acceptable to threaten people so much, just for the sake of an experiment See Vrij (2002b) for a discussion concerning ethical issues in deception research Whatever researchers try, the best insight into deceptive behaviour in real-life situations will be obtained by examining people s behaviour in such situations This is exactly what some researchers recently did (Davis and Hadiks, 1995; Vrij and Mann, 2001b; Mann et al, 2002) For example, Vrij and Mann (2001b) examined videotapes of a murderer when he was questioned by the police regarding his crime The man initially denied having committed the crime, but confessed following the presentation of indisputable evidence.

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