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53 The high error rate of RNA viruses due to the low delity of RNA polymerases has been proposed as an evolutionary advantage, but a small increase in the error rate, produced by ribavirin, may lead to a lethal loss of genome viability and virus infectivity For instance, it was shown that the anti-poliovirus activity of the drug correlated with its mutagenic effect supporting the theory that the mechanism termed lethal mutagenesis may be the primary mode of action of the drug in this system54 However, a recent report has demonstrated that the inhibitory effect of ribavirin on multiplication of the arenavirus LCMV was not associated with a signi cant increase in mutation frequencies in the virus genome, but rather with the abrogation of RNA synthesis mediated by the viral polymerase55 The multiple mechanisms of action of ribavirin also include in vivo indirect immune-mediated activities.

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In the last set of experiments we evaluate the performance of the four different functions for varying the transmission range of the particles when phase 3 is activated. We use a similar setting as in the previous experiments; that is, the eld size is 2000 m by 2000 m, and we deploy n = 5000 sensors and generate 9000 events. The result of this set of experiments are shown in Figures 15.17 15.22.

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TDmaChannel is the base class for a DMA channel. We derive three different channel classes from this as follows: TDmaSbChannel a single-buffer DMA channel TDmaDbChannel a double-buffer DMA channel TDmaSgChannel a scatter-gather DMA channel. These in turn are base classes, and the programmers creating a new phone platform will derive a platform-speci c channel object from whichever of these is appropriate for the buffering scheme that the controller hardware provides. In the diagram, I ve assumed scatter-gather mode and shown it as TPlatSgChannel. When the DMA framework extension is initialized at system boot time, an instance of this derived channel class is created for each general-purpose hardware channel that the controller manages. The TDmaChannel class is one of the two major elements of the DMA API provided to device drivers. (The other is the DDmaRequest class that I will introduce later.) The main public parts of this class and data members are as follows:

400 350 Alive Particles 300 250 200 150 100 50 0 0 2 4 6 8 10 12 14 16 18 20 22 24 26 28 30 32 Distance from Sink (section)

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56 Ribavirin has been used to treat human patients infected with respiratory syncytial virus57 and, in combination with interferon-a, is one of the current therapies approved for treatment of chronic or acute hepatitis C virus infections58 The rst experiments in animal models to test the ef cacy of ribavirin against arenaviruses were successfully carried out with LASV in primates59 Later, a controlled trial in Sierra Leone, West Africa, proved that ribavirin was very effective when administered intravenously during the rst 6 days after the onset of Lassa fever, signi cantly decreasing case-fatality rates from 50% to 5 9%49 Currently, ribavirin is the recommended treatment for patients diagnosed with Lassa fever and is also advised as a prophylactic agent in cases of possible exposure to LASV However, the drug is not effective for the treatment of advanced LASV infections.

class TDmaChannel { public: // Information passed by client when opening channel struct SCreateInfo { /** ID used by PSL to select channel to open */ TUint32 iCookie; /** Number of descriptors this channel can use. */ TInt iDesCount; /** DFC queue used to service DMA interrupts. */ TDfcQue* iDfcQ; /** DFC priority */ TUint8 iDfcPriority; }; public: static TInt Open(const SCreateInfo& aInfo, TDmaChannel*& aChannel); void Close(); void CancelAll(); inline TBool IsOpened() const; inline TBool IsQueueEmpty() const; protected: TDmac* iController; //DMAC this channel belongs to. TDfc iDfc; //Transfer complete/failure DFC. SDmaDesHdr* iCurHdr; //Fragment being transferred. SDblQue iReqQ; //Being/about to be transferred request queue. TInt iReqCount; //Number of requests attached to this channel };

Figure 15.16. Alive particles (hA ) for VTRP at different time instances (n = 5000).

It must also be remarked that undesirable secondary reactions such as.

The TDmaChannel class has a pointer to the controller object that manages the channel: iController. It also owns a DFC object iDfc, which is called whenever a request for this channel completes.

1 0.9 0.8 0.7 Success Rate 0.6 0.5 0.4 0.3 0.2 0.1 0 0 1000 2000 3000 4000 5000 6000 7000 8000 9000 Number of Events

The results indicate that the constant progress seems to be the least ef cient function regarding the success rate metric (Figure 15.17), while for the other three functions the achieved success rate seems to be at similar levels. In fact, this is also the case for the total energy consumption (Figure 15.18). The constant progress function seems to be the most conservative; however; as in the case of LTP, it actually implies that VTRPC just fails to reach the sink.

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