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The model is fit to cases in P00 and P01, and missing values of Y2 in P00 are imputed ^ by substituting the observed covariates, the imputed Y1 and the propensity score Y1 into the above formula. For a general pattern of missing data, the sequential imputation methods of Raghunathan et al. (2001) can be extended to provide PSPP imputations that condition on the spline of the propensity that each variable is missing. An (2005) discusses these extensions in detail. 18.5 EXTENSIONS TO INFERENCES OTHER THAN MEANS

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Acute TMJ disc displacement without reduction can generally be treated by conservative therapies (see chapter 10, Acute TMJ Disc Displacement without Reduction ). Invasive procedures are an option if a patient does not appear to be improving from the conservative therapy, is frustrated with the slow progress, or desires to obtain the rapid improvement generally achieved through arthrocentesis or arthroscopic surgery.65,73 Studies show conservative therapy, arthrocentesis, and arthroscopic surgery provide a similar degree of improvement for this disorder.73,80 82 Flushing the pain and in ammatory mediators out of the TMJ appear to eliminate the TMJ pain caused by these mediators, and mobilizing the mandible during these procedures appears to rapidly stretch the retrodiscal tissue and/or adhesions, thereby enabling patients to regain a normal opening.68 If the perpetuating contributing factors (parafunctional habits, etc.) are not adequately controlled prior to the procedure, the in ammatory and pain mediators may return after the surgery,80,83 and the contributing factors will then need be addressed to resolve the new symptoms. Consider referring patients whose TMD symptoms are due to this disorder when patients (1) do not appear to be improving from the conservative therapy, (2) are frustrated with the slow progress and desire more rapid results through surgical intervention, or (3) desire to obtain the rapid improvement generally achieved through arthrocentesis or arthroscopic surgery. TMJ injections with anesthetic, steroid, and/or sodium hyaluronate (not yet approved by the FDA for use in the TMJ) have also been recommended and are reasonable considerations for treating this disorder.84,85 My most common referral to oral surgeons are patients with this disorder who do not adequately improve from conservative therapy. Keep in mind that, if the perpetuating

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Figure 5.9 Hotspot tracks in the Atlantic and Indian Oceans. Large lled circles are present day hotspots. Small lled circles de ne the modeled paths of hotspots at 5 Ma intervals. Triangles on hotspot tracks indicate radiometric ages. WM, White Mountains; PB, Parana ood basalts; EB, Etendeka ood basalts; DT, Deccan Traps (modi ed and redrawn from M ller et al., 1993, courtesy of the Geological Society of America).

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summarized in 8. The other branches present the channel use of the method s validation data ; this channel can be activated either by an intra-laboratory approach or by an interlaboratory approach.

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