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KA.Barcode Generator for ASP.NET provides selectable .Related: Crystal C# Barcode Generation , RDLC .NET Winforms Barcode Generation , Make Barcode Java This protein not only is a component of the replicative enzyme complex required for replication and transcription of viral RNAs but also plays a role in suppressing the antiviral response in Sindbis virus-infected cells nsP2 may act by decreasing interferon (IFN) production100,101 In another study, White and co-workers102 found that a single change (G to A) at nucleotide 3 of the 50 untranslated region (UTR) of the Venezuelan equine encephalitis virus (VEEV) V3000 virulent strain genome resulted in a virus that was avirulent in mice This mutant showed no growth disadvantage compared to the wild-type virus in cells derived from IFN-a/bR( / )mice Induction of IFN-a/b was the same for avirulent and virulent viruses; however, the avirulent mutant virus was more sensitive than the virulent strain to the antiviral actions of IFN-a/b Thus, increased sensitivity to IFN-a/b must play a major role in the in vivo attenuation. 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